Song Liangliang, Cai Lingchao, Gong Lei, Van der Eycken Erik V
Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China.
Key Laboratory of Chemical Biology of Fujian Province, iChEM, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China.
Chem Soc Rev. 2023 Apr 3;52(7):2358-2376. doi: 10.1039/d2cs00734g.
Copper-catalyzed enantioselective coupling has been widely investigated, which allows rapid construction of various chiral molecules. Despite important advances polar and radical mechanisms, exploring general and practical strategies for the regio-, enantio- and diastereoselective assembly of stereogenic centers is of significant value but remains highly problematic. The integration of photocatalysis with asymmetric copper catalysis could provide appealing access to the development of new reaction pathways and structurally diverse chiral compounds, and extend the boundaries of radical chemistry. This review summarizes recent advances in photoinduced copper-catalyzed enantioselective coupling reactions, and discusses the mechanistic aspects.
铜催化对映选择性偶联反应已得到广泛研究，它能够快速构建各种手性分子。尽管在极性和自由基机理方面取得了重要进展，但探索用于立体中心的区域、对映和非对映选择性组装的通用且实用的策略具有重要价值，但仍然存在很大问题。光催化与不对称铜催化的结合可为开发新的反应途径和结构多样的手性化合物提供有吸引力的途径，并扩展自由基化学的边界。本文综述了光致铜催化对映选择性偶联反应的最新进展，并讨论了其机理方面的问题。
