Su Juan, Gu Xiaoyu, Li Ji, Tao Juan, Kang Xiaojing, Wu Bin, Shan Shijun, Ang Xiaohui, Chen Xiang, Xiao Yi, Shen Minxue
Department of Dermatology, Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, 410008, Hunan, China.
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, China.
Arch Dermatol Res. 2023 Sep;315(7):2057-2064. doi: 10.1007/s00403-023-02567-9. Epub 2023 Mar 14.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Bristol Stool Form Scale (BSFS) is a widely used stool scoring method that could indirectly reflect intestinal function.
To evaluate the associations of AD with BSFS.
This was a population-based cross-sectional study of freshmen in five universities of China. AD diagnosis was performed by dermatologists according to the guideline from the American Academy of Dermatology. BSFS and covariates were collected through an online questionnaire survey. Chronic itch scores were assessed by the numeric rating scales and grouped into quartiles (Q). Mixed logistic regression models were used. Subgroup analysis was conducted by covariates. P value < 0.05 was considered statistically significant.
The prevalence of hard stools and loose stools were 8.9% and 7.6%, respectively (20,049 participants). After adjusting covariates, AD was significantly associated with hard stools (OR = 1.38, P < 0.001) and loose stools (OR = 1.24, P = 0.037). In subgroup analysis of hard stool, a stronger effect was observed in intake of milk (> 3 days/week), yogurt (> 3 days/week), pork (< 1 day/week), and higher itch scores (Q4).
This study found the relationship between AD and abnormal stool forms, and the association with hard stools might be modified by dietary factor.
特应性皮炎（AD）是一种慢性炎症性皮肤病。布里斯托大便分类法（BSFS）是一种广泛使用的大便评分方法，可间接反映肠道功能。
评估AD与BSFS之间的关联。
这是一项基于人群的对中国五所大学新生的横断面研究。AD诊断由皮肤科医生根据美国皮肤病学会的指南进行。通过在线问卷调查收集BSFS和协变量。慢性瘙痒评分采用数字评分量表进行评估，并分为四分位数（Q）。使用混合逻辑回归模型。通过协变量进行亚组分析。P值<0.05被认为具有统计学意义。
硬便和软便的患病率分别为8.9%和7.6%（20049名参与者）。调整协变量后，AD与硬便（OR=1.38，P<0.001）和软便（OR=1.24，P=0.037）显著相关。在硬便的亚组分析中，在摄入牛奶（>3天/周）、酸奶（>3天/周）、猪肉（<1天/周）以及较高瘙痒评分（Q4）的人群中观察到更强的效应。
本研究发现了AD与异常大便形态之间的关系，并且与硬便的关联可能会受到饮食因素的影响。
