[Nature of the immunotropic activity of calcium antagonists].

It was shown in experiments on CBA mice that four-fold administration of calcium antagonists (verapamil, nifedipine) in doses of 5-10 mg/kg was accompanied by the development of the immunosuppressive effect. Reactions of hypersensitivity of delayed type were inhibited to the greatest degree. To a lesser degree calcium antagonists suppressed the humoral immune responses to the thymus-dependent antigen without exerting any action on the formation of antibodies to the thymus-independent antigen.