Department of Pathological Anatomy, Hospital General de México Dr. Eduardo Liceaga, Mexico City, Mexico.
Bol Med Hosp Infant Mex. 2023 Jul 12;80(Supl 1):001-006. doi: 10.24875/BMHIM.22000050.
Mucormycosis is a rare infection caused by ubiquitous fungi of the Mucorales order that mainly affects immunocompromised patients. These fungi have an important tropism for blood vessels that allows them to spread rapidly and cause thromboembolic events.
We present a case of an 8-year-old male patient diagnosed with acute lymphoblastic leukemia treated with chemotherapy. He presented icteric syndrome, hepato-splenomegaly, and data of intestinal obstruction. Although he underwent intestinal resection, he did not improve and died. The autopsy identified disseminated mucormycosis involving the brain, lungs, esophagus, small intestine, colon, and pancreas.
Hematological neoplastic diseases and their treatment are important risk factors for developing infections by opportunistic microorganisms such as mucormycosis. Early diagnosis and adequate treatment are essential due to their intrinsic difficulty and the high mortality rate of these cases.
毛霉菌病是一种罕见的感染，由无处不在的毛霉目真菌引起，主要影响免疫功能低下的患者。这些真菌对血管有重要的趋向性，使它们能够迅速传播并引起血栓栓塞事件。
我们报告了一例 8 岁男性患者，诊断为急性淋巴细胞白血病，接受化疗治疗。他出现黄疸综合征、肝脾肿大，并出现肠梗阻的表现。尽管他接受了肠切除术，但病情并未改善并死亡。尸检发现，脑、肺、食管、小肠、结肠和胰腺均有播散性毛霉菌病。
血液系统肿瘤性疾病及其治疗是发生机会性微生物感染（如毛霉菌病）的重要危险因素。由于这些病例的固有难度和高死亡率，早期诊断和适当治疗至关重要。
