Lbban Eazaz, Ashor Ammar, Shannon Oliver M, Idris Iskandar, Siervo Mario
School of Life Sciences, The University of Nottingham Medical School, Queen's Medical Centre, Nottingham, United Kingdom; Department of Physiology, College of Medicine, Umm Al-Qura University, Mecca Saudi Arabia.
College of Medicine, University of Al-Mustansiriyah, Baghdad, Iraq.
Nutrition. 2023 May;109:111995. doi: 10.1016/j.nut.2023.111995. Epub 2023 Feb 7.
Endothelial dysfunction (ED) is an early marker of vascular damage linked to the loss of integrity of the endothelial lining and represents a key step in the pathogenesis of atherosclerosis and cardiovascular diseases (CVDs). ED may be reversible, hence the development and testing of effective early interventions could be beneficial for the prevention and treatment of CVDs. Recent studies have demonstrated that the consumption of dietary nitrate (NO), an inorganic anion that serves as a substrate for the gas transmitter nitric oxide (NO), can lower blood pressure, improve endothelial function and, in observational studies, reduce the risk for CVD. We hypothesize that the co-consumption of NO with vitamin C, which is a potent antioxidant, could enhance the "yield" of NO produced from a given NO dose byThis could translate into greater NO-dependent effects on endothelial function (EF) and overall vascular health (than may be experienced with NO supplementation alone). This review presents evidence to suggest that the combination of vitamin C and dietary nitrate could represent a promising and effective approach to improve EF and reduce CVD risk, and discuss opportunities for future research.
内皮功能障碍（ED）是血管损伤的早期标志物，与内皮细胞层完整性丧失有关，是动脉粥样硬化和心血管疾病（CVD）发病机制中的关键步骤。ED可能是可逆的，因此开发和测试有效的早期干预措施可能对CVD的预防和治疗有益。最近的研究表明，摄入膳食硝酸盐（NO），一种作为气体递质一氧化氮（NO）底物的无机阴离子，可以降低血压、改善内皮功能，并且在观察性研究中，降低CVD风险。我们假设，将NO与强效抗氧化剂维生素C共同摄入，可以提高给定剂量NO产生的“产量”。这可能转化为对内皮功能（EF）和整体血管健康产生比单独补充NO更大的NO依赖性影响。本综述提供的证据表明，维生素C和膳食硝酸盐的组合可能是改善EF和降低CVD风险的一种有前景且有效的方法，并讨论了未来研究的机会。
