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萘啶酸引起的光毒性：氧依赖性光溶血。

Phototoxicity from nalidixic acid: oxygen dependent photohemolysis.

作者信息

Fernández E, Cárdenas A M, Martínez G

机构信息

Laboratorio de Fotoquímica, Escuela de Química y Farmacia, Universidad de Valparaíso, Chile.

出版信息

Farmaco Sci. 1987 Sep;42(9):681-90.

PMID:3691790
Abstract

Erythrocyte lysis photosensitized by nalidixic acid was investigated. This photohemolysis was found to be oxygen dependent. The effects of various antioxidants and hydroxyl radical scavengers on photohemolysis induced by nalidixic acid suggested a photo-oxidative step. In addition, using the oxygen quencher histidine and the deuterium oxide effect on the singlet oxygen lifetime we obtained evidence indicative of a photodynamic mechanism mediated by oxygen singlet and hydroxyl radicals. On the other hand, pre-irradiated nalidixic acid was not lytic to erythrocytes, yet photoproducts of nalidixic acid demonstrated a greater photohemolytic potential than nalidixic acid itself.

摘要

研究了萘啶酸光敏化引起的红细胞裂解。发现这种光溶血依赖于氧气。各种抗氧化剂和羟基自由基清除剂对萘啶酸诱导的光溶血的影响表明存在一个光氧化步骤。此外，使用氧气猝灭剂组氨酸以及氧化氘对单线态氧寿命的影响，我们获得了表明由单线态氧和羟基自由基介导的光动力机制的证据。另一方面，预先照射的萘啶酸对红细胞没有裂解作用，但萘啶酸的光产物显示出比萘啶酸本身更大的光溶血潜力。

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Arch Toxicol. 1991;65(6):495-9. doi: 10.1007/BF01977363.
2
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Arch Toxicol. 1992;66(6):392-7. doi: 10.1007/BF02035128.
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Antimicrob Agents Chemother. 1992 Aug;36(8):1715-9. doi: 10.1128/AAC.36.8.1715.