α毒素对烟碱型乙酰胆碱受体的多种作用。
Multiple effects of alpha-toxins on the nicotinic acetylcholine receptor.
作者信息
Bradley R J, Pagala M K, Edge M T
机构信息
Neuropsychiatry Research Program, School of Medicine, University of Alabama at Birmingham 35294.
出版信息
FEBS Lett. 1987 Nov 30;224(2):277-82. doi: 10.1016/0014-5793(87)80469-6.
Very low concentrations (5 nM) of alpha-toxin from the venom of Naja naja atra produced a characteristic fade in muscle compound action potential and tetanus induced by repetitive nerve stimulation which was identical to the effects of curare. High concentrations of alpha-toxin and all concentrations of alpha-bungarotoxin reduced the response but produced very little fade in comparison to curare. These results suggest that alpha-toxins have more than one effect at the neuromuscular junction.
来自眼镜蛇毒液的极低浓度（5纳摩尔）的α-毒素会使肌肉复合动作电位产生特征性衰减，并使重复神经刺激诱导的强直收缩出现衰减，这与箭毒的作用相同。高浓度的α-毒素以及所有浓度的α-银环蛇毒素会降低反应，但与箭毒相比，产生的衰减非常小。这些结果表明，α-毒素在神经肌肉接头处有不止一种作用。
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