鸡睫状神经节和虹膜肌肉中的乙酰胆碱受体：眼镜蛇神经毒素的特异性结合及其对突触传递的影响
Acetylcholine receptors in the ciliary ganglion and in the iris muscle of the chick: specific binding and effect on the synaptic transmission of the neurotoxin from Naja naja siamensis.
作者信息
Conti-Tronconi B, Gotti C, Paggi P, Rossi A
出版信息
Br J Pharmacol. 1979 May;66(1):33-8. doi: 10.1111/j.1476-5381.1979.tb16094.x.
Abstract
1 A specific binding of Naja naja siamensis neurotoxin was found both in the iris and in the ciliary ganglion of the chick. 2 Naja-toxin (125 nM) caused a complete block of the iris muscle contraction induced by carbamylcholine. 3 Naja-toxin had a different effect on the two neuronal populations present in the ganglion: it blocked the synaptically evoked response of the ciliary cells, while the response of the choroid ones was only slightly reduced. The effects were the same in a wide range of concentrations (125 to 2500 nM). 4 The results obtained in the iris show the existence of an acetylcholine receptor population similar to the nicotinic receptor of the skeletal muscle. 5 In the ciliary ganglion the results confirm the existence of different acetylcholine receptors on the two cell types.
摘要
- 在鸡的虹膜和睫状神经节中均发现了眼镜蛇神经毒素的特异性结合。2. 眼镜蛇毒素（125 nM）可完全阻断由氨甲酰胆碱诱导的虹膜肌肉收缩。3. 眼镜蛇毒素对神经节中存在的两种神经元群体有不同影响：它阻断了睫状细胞的突触诱发反应，而脉络膜细胞的反应仅略有降低。在广泛的浓度范围（125至2500 nM）内效果相同。4. 在虹膜中获得的结果表明存在类似于骨骼肌烟碱受体的乙酰胆碱受体群体。5. 在睫状神经节中，结果证实了两种细胞类型上存在不同的乙酰胆碱受体。
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Acetylcholine receptors in the ciliary ganglion and in the iris muscle of the chick: specific binding and effect on the synaptic transmission of the neurotoxin from Naja naja siamensis.鸡睫状神经节和虹膜肌肉中的乙酰胆碱受体：眼镜蛇神经毒素的特异性结合及其对突触传递的影响
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