Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.
Department of Biomedical and Clinical Sciences "Luigi Sacco", Università degli studi di Milano, Milano, Italy.
Adv Exp Med Biol. 2020;1234:15-29. doi: 10.1007/978-3-030-37184-5_2.
The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as matrix and soluble factors. A switch from quiescent fibroblasts to cancer-associated fibroblasts triggers a large variety of pro-tumorigenic signals that support tumor progression and shape the surrounding pathological stroma, with the remodeling of tissue architecture and repression of the local immune response. The heterogeneous nature of cancer-associated fibroblasts and their multiple functions are subject of active research as they could represent promising targets for cutting-edge therapeutic approaches to cancer and the tumor microenvironment.
近年来，肿瘤微环境在癌症发生和发展中的意义引起了人们的兴趣。在肿瘤基质中，成纤维细胞是主要的细胞类型，负责肿瘤微环境中大多数细胞外成分，如基质和可溶性因子。成纤维细胞从静止状态向癌相关成纤维细胞的转变触发了大量促肿瘤信号，这些信号支持肿瘤的进展并塑造周围的病理基质，重塑组织结构并抑制局部免疫反应。癌相关成纤维细胞的异质性及其多种功能是当前研究的热点，因为它们可能成为癌症和肿瘤微环境的前沿治疗方法的有前途的靶点。
