Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Student Research Committee, Babol University of Medical Sciences, Babol, Iran; Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran.
J Gynecol Obstet Hum Reprod. 2023 May;52(5):102574. doi: 10.1016/j.jogoh.2023.102574. Epub 2023 Mar 12.
We aimed to collect recent findings for a deeper understanding of the association between human exposure to polychlorinated biphenyls (PCBs) and endometriosis development.
Web of Science, PubMed, Scopus, Google Scholar, and Embase were searched based on inclusion criteria from 2000 to the end of 2020. No filter was exerted to limit the language of publications and geographical restriction. Odds ratios (OR) using the random-effects model and the corresponding 95% confidence interval (CI) were calculated for each included study.
Fourteen studies were included in our analyses. The pooled OR and 95% CI for PCB was 1.96 (1.31 to 2.93). Despite being statistically significant, there was evidence of moderate heterogeneity (I = 63%, P = 0.001, τ = 0.32). Findings from our subgroup analyses showed a significant association between PCB exposure and endometriosis among European population (OR = 3.66, 95% CI: 2.08-6.44). Also a positive association was detected between PCB exposure and an increased odds of endometriosis in studies with laparoscopy (OR = 2.32, 95% CI: 1.16-4.63) or surgery confirm of controls (OR = 1.39, 95% CI: 1.02-1.89). Moreover, according to matched-pairs design, a significant association between PCB exposure and endometriosis development was detected (OR = 1.51, 95% CI: 1.04-2.18), also heterogeneity decreased in studies with matched-pairs design (I = 30.4%).
Findings of this study confirm an association between endometriosis and exposure to PCB. However, more primary studies using proper methodology are needed to confirm this association.
本研究旨在收集最新研究结果，以深入了解人类接触多氯联苯（PCBs）与子宫内膜异位症发展之间的关联。
我们根据纳入标准，从 2000 年到 2020 年底，在 Web of Science、PubMed、Scopus、Google Scholar 和 Embase 上进行了搜索。未设置过滤器来限制出版物的语言和地理限制。对于每项纳入的研究，使用随机效应模型计算比值比（OR）及其相应的 95%置信区间（CI）。
我们的分析纳入了 14 项研究。PCBs 的汇总 OR 和 95%CI 为 1.96（1.31-2.93）。尽管具有统计学意义，但存在中度异质性的证据（I=63%，P=0.001，τ=0.32）。我们的亚组分析结果表明，PCBs 暴露与欧洲人群的子宫内膜异位症之间存在显著关联（OR=3.66，95%CI：2.08-6.44）。在腹腔镜检查（OR=2.32，95%CI：1.16-4.63）或手术确认对照组（OR=1.39，95%CI：1.02-1.89）的研究中，也检测到 PCBs 暴露与子宫内膜异位症发生几率增加之间存在正相关。此外，根据配对设计，在 PCBs 暴露与子宫内膜异位症发展之间检测到显著关联（OR=1.51，95%CI：1.04-2.18），在具有配对设计的研究中，异质性也降低（I=30.4%）。
本研究的结果证实了子宫内膜异位症与接触 PCB 之间存在关联。然而，需要更多使用适当方法学的原始研究来证实这种关联。
