Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University Hospital, 377-2 Ohno-Higashi, Osakasayama, Osaka, 589-8511, Japan.
Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Japan.
J Nucl Cardiol. 2023 Oct;30(5):1879-1885. doi: 10.1007/s12350-023-03236-0. Epub 2023 Mar 14.
The aim of this study was to estimate the impact of respiratory and electrocardiogram (ECG)-gated FDG positron emission tomography (PET)/computed tomography (CT) on the diagnosis of cardiac sarcoidosis (CS).
Imaging from thirty-one patients was acquired on a PET/CT scanner equipped with a respiratory- and ECG-gating system. Non-gated PET images and three kinds of gated PET/CT images were created from identical list-mode clinical PET data: respiratory-gated PET during expiration (EX), ECG-gated PET at end diastole (ED), and ECG-gated PET at end systole (ES). The maximum standardized uptake value (SUVmax) and cardiac metabolic volume (CMV) were measured, and the locations of FDG accumulation were analyzed using a polar map. The mean SUVmax of the subjects was significantly higher after application of either respiratory-gated or ECG-gated reconstruction. Conversely, the mean CMV was significantly lower following the application of respiratory-gated or ECG-gated reconstruction. The segment showing maximum accumulation was shifted to the adjacent segment in 25.8%, 38.7%, and 41.9% of cases in EX, ED, and ES images, respectively.
In FDG PET/CT scanning for the diagnosis of CS, gated scanning is likely to increase quantitative accuracy, but the effect depends on the location and synchronization method.
本研究旨在评估呼吸门控和心电图（ECG）门控 FDG 正电子发射断层扫描（PET）/计算机断层扫描（CT）对心脏结节病（CS）诊断的影响。
使用配备呼吸和心电图门控系统的 PET/CT 扫描仪获取 31 例患者的图像。从相同的列表模式临床 PET 数据创建非门控 PET 图像和三种门控 PET/CT 图像：呼气时的呼吸门控 PET（EX）、舒张末期的 ECG 门控 PET（ED）和收缩末期的 ECG 门控 PET（ES）。测量最大标准化摄取值（SUVmax）和心脏代谢体积（CMV），并使用极地图分析 FDG 积聚的位置。应用呼吸门控或 ECG 门控重建后，受试者的平均 SUVmax 显著升高。相反，应用呼吸门控或 ECG 门控重建后，平均 CMV 显著降低。在 EX、ED 和 ES 图像中，最大累积的节段分别有 25.8%、38.7%和 41.9%转移到相邻节段。
在用于诊断 CS 的 FDG PET/CT 扫描中，门控扫描可能会提高定量准确性，但效果取决于位置和同步方法。
