Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Oral Biology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Sci Rep. 2023 Mar 14;13(1):4198. doi: 10.1038/s41598-023-31282-8.
Aloe vera has antimicrobial activity and enhances the osseointegration process, thus it may have the potential in treating periodontal defects. This study aimed to evaluate the effect of Aloe vera as an adjunction to Beta-tricalcium phosphate (β-TCP) bone graft in Grade II furcation defects. A randomized study was conducted on six healthy mongrel dogs' premolars. A total of twenty-four Grade II furcation critical-sized defects were surgically created after reflecting a full-thickness flap, twelve defects were filled with β-TCP while the other twelve defects were filled with Aloe vera mixed with β-TCP and both covered by collagen membrane. Animals were euthanized at the end of the fourth and eighth week and defects were analyzed histologically and histomorphometrically. Histologically, Aloe vera mixed with β-TCP resulted in more bone formation and new PDL fibers compared to β-TCP alone. After 2 and 4 weeks, the experimental group had significantly higher newly formed interradicular bone height (p < 0.0001, and p < 0.0001, respectively), bone thickness (p < 0.0001, and p < 0.0001, respectively), and percentage of the surface area (p = 0.009, and p = 0.023, respectively). Aloe vera gel adjunctive to β-TCP is an effective bioactive agent that enhances periodontal tissue regeneration and bone formation in critically sized defects.
芦荟具有抗菌活性，并能增强骨整合过程，因此它可能具有治疗牙周缺损的潜力。本研究旨在评估芦荟作为 β-磷酸三钙（β-TCP）骨移植的附加物在 II 度分叉缺损中的作用。对 6 只健康杂种犬的前磨牙进行了一项随机研究。在翻瓣后形成全厚瓣后，共创建了 24 个 II 度分叉临界尺寸缺损，其中 12 个缺损用 β-TCP 填充，而另 12 个缺损用芦荟混合 β-TCP 填充，并均用胶原膜覆盖。动物在第 4 和第 8 周末被安乐死，然后对缺损进行组织学和组织形态计量学分析。组织学上，与单独使用 β-TCP 相比，芦荟混合 β-TCP 导致更多的骨形成和新的牙周膜纤维。在 2 和 4 周后，实验组的新生根间骨高度明显更高（p<0.0001 和 p<0.0001）、骨厚度（p<0.0001 和 p<0.0001）和表面面积百分比（p=0.009 和 p=0.023）。芦荟凝胶作为 β-TCP 的附加物是一种有效的生物活性剂，可增强临界尺寸缺损中牙周组织的再生和骨形成。
