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用于小儿头皮重建且并发土曲霉真菌感染的组织扩张器

Tissue Expander for Pediatric Scalp Reconstruction Complicated by Fungal Infection With Aspergillus terreus.

作者信息

Edwards Shelley R, Benedict Katherine C, Sullivan John, Santos Roberto, Hoppe Ian

机构信息

University of Mississippi Medical Center, Division of Plastic and Reconstructive Surgery, Jackson, MS.

University of Mississippi Medical Center, Department of Pediatrics, Jackson, MS.

出版信息

Eplasty. 2023 Feb 6;23:e9. eCollection 2023.

Abstract

BACKGROUND

Tissue expansion is an effective option for soft tissue reconstruction of the scalp in the pediatric population. Unfortunately, this approach carries a high risk of such complications as infection and expander exposure. While bacterial infection of alloplastic materials is most frequent, when fungal infections occur, the outcomes can be devastating.

PURPOSE

To inform the management of fungal tissue expander infections, this report describes a case of expander-based scalp reconstruction complicated by infection in a pediatric patient.

METHODS

A patient who had blunt-force head trauma presented with soft tissue injury and depressed skull fracture requiring emergent craniectomy. After stabilization, a paucity of soft tissue coverage required further surgical intervention before reconstructive cranioplasty. Six months after her injury, two remote port subgaleal tissue expanders were placed. Subsequently, purulent drainage developed from the surgical incision.

RESULTS

Infection resulted in expander exposure requiring device removal and treatment with clindamycin and ceftazidime while awaiting culture results. Intraoperative cultures were positive for and methicillin-sensitive for which she received systemic voriconazole for 23 days and cephalexin for 10 days.

CONCLUSIONS

Though tissue expansion remains a viable reconstructive option, fungal infection can be disastrous, requiring systemic antifungal therapy, surgical debridement, and expander removal.

摘要

背景

组织扩张术是小儿头皮软组织重建的一种有效方法。不幸的是,这种方法存在感染和扩张器外露等并发症的高风险。虽然异体材料的细菌感染最为常见,但真菌感染一旦发生,后果可能是毁灭性的。

目的

为了指导真菌性组织扩张器感染的处理,本报告描述了一例小儿患者基于扩张器的头皮重建并发感染的病例。

方法

一名因钝器头部外伤导致软组织损伤和颅骨凹陷性骨折的患者,需要紧急开颅手术。病情稳定后,由于软组织覆盖不足,在进行重建颅骨成形术前需要进一步的手术干预。受伤6个月后,植入了两个远端端口帽状腱膜下组织扩张器。随后,手术切口出现脓性引流。

结果

感染导致扩张器外露,需要取出装置,并在等待培养结果期间使用克林霉素和头孢他啶进行治疗。术中培养结果显示对 呈阳性,对甲氧西林敏感,为此她接受了23天的全身性伏立康唑治疗和10天的头孢氨苄治疗。

结论

尽管组织扩张术仍然是一种可行的重建选择,但真菌感染可能是灾难性的,需要全身性抗真菌治疗、手术清创和取出扩张器。

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本文引用的文献

1
Aspergillus terreus Species Complex.土曲霉物种复合体。
Clin Microbiol Rev. 2021 Dec 15;34(4):e0031120. doi: 10.1128/CMR.00311-20. Epub 2021 Jun 30.
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Fungal infections in pediatric neurosurgery.儿科神经外科中的真菌感染
Childs Nerv Syst. 2018 Oct;34(10):1973-1988. doi: 10.1007/s00381-018-3942-3. Epub 2018 Aug 18.
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Infection of tissue expander with Candida parapsilosis.
Eplasty. 2012;12:ic7. Epub 2012 May 22.
9
Fungal colonization within a tissue expander: a case report.
Ann Plast Surg. 2012 Feb;68(2):150-2. doi: 10.1097/SAP.0b013e31823dcda7.

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