Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
J Periodontol. 2023 Aug;94(8):976-985. doi: 10.1002/JPER.22-0654. Epub 2023 Apr 4.
Trans fatty acid (TFA) consumption has been reported to harbor proinflammatory characteristics and increasing oxidative stress properties, but there has been little research into its association with periodontitis. This study aimed to explore the potential association between TFAs and periodontitis.
This large population-based study included participants from the National Health and Nutrition Examination Survey (2009-2010). Weighted binary and ordinal logistic regressions were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the relationship between plasma TFAs and periodontitis.
A total of 1433 eligible participants, 793 (55.3%) participants with periodontitis and 640 (44.7%) without periodontitis were included. Univariate logistic regression revealed significant associations between plasma trans-11-octadecenoic acid, trans-9-octadecenoic acid, the sum of trans-octadecenoic acids, and the sum of TFAs and periodontitis (all P < 0.01). After controlling for the potential confounders, these four types of TFAs remained significantly associated with periodontitis (the ORs and 95% CIs per interquartile range increase were 1.16 (1.01-1.33), 1.20 (1.03-1.39), 1.18 (1.02-1.35), and 1.17 (1.01-1.35), respectively). Notably, these positive associations were more pronounced among overweight/obese populations. Additionally, plasma trans-9-octadecenoic acid levels were found to be associated with periodontitis severity.
This study suggests a significant positive association between certain plasma TFAs and chronic periodontitis, especially among overweight/obese populations. These findings provide new insights into periodontitis prevention from a dietary perspective.
反式脂肪酸（TFA）的摄入被报道具有促炎特性和增加氧化应激特性，但关于其与牙周炎的关系研究甚少。本研究旨在探讨 TFAs 与牙周炎之间的潜在关联。
本大规模基于人群的研究纳入了来自国家健康与营养调查（2009-2010 年）的参与者。使用加权二项和有序逻辑回归计算比值比（ORs）和 95%置信区间（CIs），以评估血浆 TFAs 与牙周炎之间的关系。
共纳入 1433 名符合条件的参与者，其中 793 名（55.3%）患有牙周炎，640 名（44.7%）无牙周炎。单变量逻辑回归显示，血浆反式-11-十八碳烯酸、反式-9-十八碳烯酸、反式十八碳烯酸总和和 TFA 总和与牙周炎之间存在显著关联（均 P<0.01）。在控制了潜在混杂因素后，这四种 TFA 仍与牙周炎显著相关（每增加一个四分位间距的 OR 和 95%CI 分别为 1.16（1.01-1.33）、1.20（1.03-1.39）、1.18（1.02-1.35）和 1.17（1.01-1.35））。值得注意的是，这些正相关在超重/肥胖人群中更为明显。此外，血浆反式-9-十八碳烯酸水平与牙周炎严重程度相关。
本研究表明，某些血浆 TFAs 与慢性牙周炎之间存在显著的正相关关系，尤其是在超重/肥胖人群中。这些发现为从饮食角度预防牙周炎提供了新的见解。
