Department of Neurology, Jinshan Hospital, Fudan University, Shanghai, China, 201508.
Department of Neurology, Jinshan Hospital, Fudan University, Shanghai, China, 201508.
Prostaglandins Leukot Essent Fatty Acids. 2024 Feb;201:102624. doi: 10.1016/j.plefa.2024.102624. Epub 2024 May 31.
Trans-fatty acid (TFA) has been linked to an increased risk of a variety of diseases, such as cardiovascular disease (CVD), diabetes, and cancer. However, the relationship between plasma TFAs and migraine is little known. The current study aimed to determine the association between plasma TFAs and migraine in a large cross-sectional study among U.S. adults.
The participants from the US National Health and Nutrition Examination Survey (NHANES) were included during the period 1999-2000. The plasma concentrations of four major TFAs, including palmitelaidic acid (C16:1n-7t), elaidic acid (C18:1n-9t), vaccenic acid (C18:1n-7t), and linolelaidic acid (C18:2n-6t, 9t) were measured by gas chromatography/mass spectrometry (GC/MS). The presence of migraine headache was determined by self-report questionnaire. Weighted multivariable logistic regressions and restricted cubic spline (RCS) regressions were explored to assess the relationship between plasma TFAs and migraine. Furthermore, stratified analysis and testing of interaction terms were used to evaluate the effect modification by sex, age, race/ethnicity, family income, and BMI.
A total of 1534 participants were included. The overall weighted prevalence of severe headache or migraine was 21.2 %. After adjusting for all potential covariates, plasma levels of elaidic acid and linolelaidic acid were positively associated with migraine. The adjusted OR values were 1.18 (95 %CI: 1.08-1.29, p=0.014, per 10 units increase) and 1.24 (95 %CI: 1.07-1.44, p=0.024). Then the included participants were divided into 2-quantiles by plasma TFA levels. Compared with participants with lower plasma levels of elaidic acid and linolelaidic acid (Q1 groups), those in the Q2 group had a higher prevalence of migraine when adjusted for all covariates in Model 2. The adjusted OR values were 2.43 (95 %CI: 1.14-5.18, p=0.037) for elaidic acid, and 2.18 (95 %CI: 1.14-4.20, p=0.036) for linolelaidic acid. Results were robust when analyses were stratified by sex, age, race/ethnicity, family income, and BMI, and no effect modification on the association was found.
Our results demonstrated a positive association between migraine prevalence and plasma levels of elaidic acid and linolelaidic acid in US adults. These results highlight the connection between circulating TFAs and migraine.
反式脂肪酸（TFA）与多种疾病的风险增加有关，例如心血管疾病（CVD）、糖尿病和癌症。然而，血浆 TFAs 与偏头痛之间的关系鲜为人知。本研究旨在通过美国成年人的大型横断面研究来确定血浆 TFAs 与偏头痛之间的关联。
研究对象来自美国国家健康与营养检查调查（NHANES），时间为 1999-2000 年。通过气相色谱/质谱（GC/MS）测量四种主要 TFAs 的血浆浓度，包括棕榈烯酸（C16：1n-7t）、反式油酸（C18：1n-9t）、vaccenic 酸（C18：1n-7t）和亚油酸（C18：2n-6t、9t）。偏头痛头痛的存在通过自我报告问卷确定。使用加权多变量逻辑回归和受限立方样条（RCS）回归来评估血浆 TFAs 与偏头痛之间的关系。此外，还进行了分层分析和交互项检验，以评估性别、年龄、种族/民族、家庭收入和 BMI 的效应修饰作用。
共纳入 1534 名参与者。严重头痛或偏头痛的总加权患病率为 21.2%。在调整所有潜在协变量后，反式油酸和亚油酸的血浆水平与偏头痛呈正相关。调整后的 OR 值分别为 1.18（95%CI：1.08-1.29，p=0.014，每增加 10 个单位）和 1.24（95%CI：1.07-1.44，p=0.024）。然后，根据血浆 TFA 水平将纳入的参与者分为 2 个四分位数。与反式油酸和亚油酸血浆水平较低（Q1 组）的参与者相比，调整模型 2 中的所有协变量后，Q2 组偏头痛的患病率更高。调整后的 OR 值分别为反式油酸 2.43（95%CI：1.14-5.18，p=0.037）和亚油酸 2.18（95%CI：1.14-4.20，p=0.036）。当按性别、年龄、种族/民族、家庭收入和 BMI 进行分层分析时，结果仍然稳健，并且没有发现对关联的效应修饰作用。
我们的研究结果表明，美国成年人偏头痛患病率与血浆反式油酸和亚油酸水平之间存在正相关。这些结果强调了循环 TFAs 与偏头痛之间的联系。
