Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, 310000, China.
BMC Oral Health. 2024 May 8;24(1):541. doi: 10.1186/s12903-024-04316-4.
Widespread exposure to phthalates may raise the probability of various diseases. However, the association of phthalate metabolites with periodontitis remains unclear.
Totally 3402 participants from the National Health and Nutrition Examination Survey (NHANES) 2009 to 2014 cycles were enrolled in the cross-sectional investigation. We utilized weighted logistic regression to evaluate the association of ten phthalate metabolites with periodontitis. Restricted cubic spline analysis was applied to investigate potential nonlinear relationships.
The weighted prevalence of periodontitis in the study was 42.37%. A one standard deviation (SD) rise in log-transformed levels of mono-2-ethyl-5-carboxypenty phthalate (MECPP), mono-n-butyl phthalate (MnBP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-isobutyl phthalate (MiBP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-benzyl phthalate (MBzP) was associated with higher odds of periodontitis, with odds ratios (95% confidence intervals) of 1.08 (1.02-1.14), 1.07 (1.02-1.11), 1.10 (1.05-1.15), 1.05 (1.01-1.09), 1.09 (1.04-1.14), and 1.08 (1.03-1.13), respectively. Individuals with the highest quartile concentrations of MECPP, MnBP, MEHHP, MEOHP, and MBzP were associated with 32%, 20%, 30%, 25%, and 26% increased odds of periodontitis, respectively, compared to those with the lowest quartile. Additionally, mono-(3-carboxypropyl) phthalate (MCPP) demonstrated an interesting inverted J-shaped relationship with periodontitis.
The findings indicate an association of certain phthalate metabolites with periodontitis among US adults.
广泛接触邻苯二甲酸酯可能会增加各种疾病的发病概率。然而，邻苯二甲酸酯代谢物与牙周炎之间的关联尚不清楚。
本横断面研究共纳入了来自 2009 至 2014 年国家健康和营养调查（NHANES）的 3402 名参与者。我们采用加权逻辑回归评估了 10 种邻苯二甲酸酯代谢物与牙周炎之间的关系。采用限制性立方样条分析来探讨潜在的非线性关系。
研究中牙周炎的加权患病率为 42.37%。与最低四分位浓度相比，邻苯二甲酸单-2-乙基-5-羧基戊基酯（MECPP）、邻苯二甲酸单正丁基酯（MnBP）、邻苯二甲酸单-（2-乙基-5-羟己基）酯（MEHHP）、邻苯二甲酸单异丁基酯（MiBP）、邻苯二甲酸单-（2-乙基-5-氧己基）酯（MEOHP）和邻苯二甲酸单苄基酯（MBzP）的对数变换水平升高一个标准差与牙周炎的发病几率更高相关，比值比（95%置信区间）分别为 1.08（1.02-1.14）、1.07（1.02-1.11）、1.10（1.05-1.15）、1.05（1.01-1.09）、1.09（1.04-1.14）和 1.08（1.03-1.13）。与最低四分位浓度相比，MECPP、MnBP、MEHHP、MEOHP 和 MBzP 的四分位浓度最高的个体患牙周炎的几率分别增加了 32%、20%、30%、25%和 26%。此外，邻苯二甲酸单（3-羧基丙基）酯（MCPP）与牙周炎呈有趣的倒 J 形关系。
研究结果表明，某些邻苯二甲酸酯代谢物与美国成年人的牙周炎有关。
