Ramle Abdul Qaiyum, Tiekink Edward R T
School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
Research Centre for Crystalline Materials, School of Medical and Life Sciences, Sunway University, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.
Org Biomol Chem. 2023 Apr 5;21(14):2870-2888. doi: 10.1039/d3ob00192j.
Dibenzo[1,5]diazocine scaffolds are present in a wide range of organic building blocks, for example in pharmaceuticals, materials and structural chemistry. However, the development of these structural frameworks has not received significant attention owing to limited synthetic protocols and strategies. Herein, a summary of the attractive synthetic approaches for the construction of dibenzo[1,5]diazocines, epiminodibenzo[1,5]diazocines and epoxydibenzo[1,5]diazocines developed over the past two decades is presented. The spectroscopic, synthetic mechanisms for the formation of the heterocyclic rings and remarkable structural features, including in the solid-state, are discussed.
二苯并[1,5]二氮杂环辛烷骨架存在于多种有机结构单元中，例如在药物、材料和结构化学领域。然而，由于合成方法和策略有限，这些结构框架的开发尚未受到足够的关注。本文总结了过去二十年来用于构建二苯并[1,5]二氮杂环辛烷、表亚氨基二苯并[1,5]二氮杂环辛烷和环氧二苯并[1,5]二氮杂环辛烷的有吸引力的合成方法。讨论了杂环形成的光谱、合成机理以及显著的结构特征，包括固态结构特征。
