Koroleva Elizaveta A, Shabalkin Ilya D, Krivoshapkin Pavel V
EnergyLab, ITMO University, Saint Petersburg 191002, Russian Federation.
J Mater Chem B. 2023 Apr 5;11(14):3054-3070. doi: 10.1039/d2tb02169b.
Current intrinsic deficiencies in biomedicine promote the rapid development of alternative multitasking approaches. Recently, monometallic and alloy nanoparticles (NPs) have been widely studied for their potential biomedical applications. However, the research mainly focuses on monometallic compounds and metal oxide NPs that have already been studied. In this review, we investigate promising modified mono- and bimetallic NPs for improving the current state of materials science in medicine. It was contended that effective general biomedical applications can be enhanced by intelligent NP design. Particularly, we discuss transition and platinum metal compositions, iron-based and non-iron compounds, along with liquid alloys. Subsequently, we explore the capabilities provided by modifications such as inorganic and organic coatings, polymers, and biomolecules that can invent new NP designs for precise applications, ultimately resulting in an improved patient outcome. We provide a comprehensive assessment of the advantages and limitations of monometallic and alloy nanomaterials and possible solutions to problems that delay their development.
当前生物医学领域固有的缺陷推动了替代性多任务方法的快速发展。最近，单金属和合金纳米颗粒（NPs）因其潜在的生物医学应用而受到广泛研究。然而，该研究主要集中在已经研究过的单金属化合物和金属氧化物纳米颗粒上。在本综述中，我们研究了有前景的改性单金属和双金属纳米颗粒，以改善医学材料科学的现状。有人认为，通过智能纳米颗粒设计可以增强有效的一般生物医学应用。特别是，我们讨论了过渡金属和铂金属成分、铁基和非铁化合物以及液态合金。随后，我们探索了无机和有机涂层、聚合物和生物分子等改性所提供的能力，这些改性可以为精确应用发明新的纳米颗粒设计，最终改善患者的治疗效果。我们对单金属和合金纳米材料的优缺点以及阻碍其发展的问题的可能解决方案进行了全面评估。
