镰刀菌色原酮和T-2毒素对单层培养关节软骨细胞的影响。
Effect of fusarochromanone and T-2 toxin on articular chondrocytes in monolayer culture.
作者信息
Wright G C, Marasas W F, Sokoloff L
机构信息
Department of Pathology, State University of New York, Stony Brook 11794.
出版信息
Fundam Appl Toxicol. 1987 Oct;9(3):595-7. doi: 10.1016/0272-0590(87)90040-6.
The effect of fusarochromanone and T-2 toxin on DNA synthesis and radio-sulfate incorporation by rabbit articular chondrocytes was studied in monolayer culture. T-2 toxin reduced DNA more than 50% at 5 x 10(-9) M; fusarochromanone caused small but progressive decrements over a range of 5 x 10(-8) to 10(-6) M. These actions are not specific for chondrocytes. The findings lend no support to the hypothesis that fusarochromanone, at least in unmodified form, is the etiologic agent in Kashin-Beck disease.
在单层培养中研究了镰孢菌色原酮和T-2毒素对兔关节软骨细胞DNA合成及放射性硫酸盐掺入的影响。T-2毒素在5×10⁻⁹ M时使DNA减少超过50%；镰孢菌色原酮在5×10⁻⁸至10⁻⁶ M范围内引起微小但逐渐增加的减少。这些作用并非软骨细胞所特有。这些发现不支持镰孢菌色原酮（至少未修饰形式）是大骨节病病因的假说。
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