School of Psychology, Southwest University, Chongqing.
School of Nursing, Guizhou Medical University, Guizhou.
Clin J Pain. 2023 May 1;39(5):209-216. doi: 10.1097/AJP.0000000000001103.
Elevations in pain catastrophizing (PC) are associated with more severe pain, emotional distress, and impairment within samples with chronic pain. However, brain structure correlates underlying individual differences in PC are not well understood and predict more severe pain and impairment within samples with chronic pain. This study assessed links between regional gray matter volume (GMV) and individual differences in PC within a large mixed chronic pain sample.
Chinese adult community dwellers with chronic pain of at least 3 months duration (101 women and 59 men) completed self-report measures of background characteristics, pain severity, depression, and a widely validated PC questionnaire as well as a structural magnetic resonance imagining scan featuring voxel-based morphology to assess regional GMV correlates of PC.
After controlling for demographic correlates of PC, pain severity, and depression, higher PC scores had a significant, unique association with lower GMV levels in the inferior temporal area of the right fusiform gyrus, a region previously implicated in emotion regulation.
GMV deficits, particularly in right temporal-occipital emotion regulation regions, correspond to high levels of PC among individuals with chronic pain.
在慢性疼痛样本中，疼痛灾难化（PC）的升高与更严重的疼痛、情绪困扰和功能障碍有关。然而，个体差异的 PC 背后的大脑结构相关性尚不清楚，并且预测了慢性疼痛样本中更严重的疼痛和功能障碍。本研究评估了区域性灰质体积（GMV）与大型混合慢性疼痛样本中个体差异 PC 之间的联系。
患有至少 3 个月慢性疼痛的中国成年社区居民（101 名女性和 59 名男性）完成了背景特征、疼痛严重程度、抑郁和广泛验证的 PC 问卷以及结构磁共振成像扫描，以评估 PC 的区域性 GMV 相关性。
在控制了 PC 的人口统计学相关性、疼痛严重程度和抑郁之后，较高的 PC 评分与右侧梭状回下颞区的 GMV 水平降低有显著的、独特的关联，该区域以前与情绪调节有关。
GMV 缺陷，特别是在右颞枕部情绪调节区域，与慢性疼痛个体中高水平的 PC 相对应。
