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老年人慢性瘙痒症和湿疹/皮炎的治疗策略属于老年慢性湿疹性发作(CEEA)类别。

Treatment Strategies for Chronic Pruritus and Eczema/Dermatitis in Older Adults Under the Category of Chronic Eczematous Eruptions of Aging (CEEA).

机构信息

University of Arizona, College of Medicine, 1501 N Campbell Ave, Tuscon, AZ, 85724, USA.

University of Utah, School of Medicine, Salt Lake City, UT, USA.

出版信息

Am J Clin Dermatol. 2023 May;24(3):405-418. doi: 10.1007/s40257-023-00767-7. Epub 2023 Mar 15.

Abstract

Chronic eczematous eruptions of aging (CEEA) refers to a heterogenous group of longstanding, pruritic eczematous dermatoses with an unidentified etiology, or those which do not meet strict disease criteria. The literature has not yet established a single ubiquitous disease or term for these eruptions in adults over the age of 65 years. Instead, CEEA is attributed various names, including immunologic eruption of aging, and eruption of immunosenescence. Atopic dermatitis in the elderly, eczema in the elderly, and late- or adult-onset atopic dermatitis or eczema likely also fall under the umbrella of CEEA, given that older patients often do not meet strict criteria for atopic dermatitis. As a reflection of such terminological heterogeneity, CEEA does not have a standardized workup algorithm. This lack of uniformity can obscure the ability to study and understand appropriate treatments for this condition. Yet, as providers become increasingly aware of CEEA and more comfortable in making this diagnosis in older adults, it is necessary that dermatologists understand the safety and efficacy of common CEEA treatments in this population. Here, we discuss special considerations, challenges, and recommendations for treating older adults with CEEA with topical and systemic therapeutics. We provide an overview of therapeutic strategies and potential barriers to treatment and discuss the essential role of shared decision making when caring for this patient population.

摘要

老年慢性湿疹性发作(CEEA)是指一组病因不明的长期瘙痒性湿疹性皮肤病,或那些不符合严格疾病标准的皮肤病。文献尚未为 65 岁以上成年人的这些发作确定单一的普遍疾病或术语。相反,CEEA 被赋予了各种名称,包括老年免疫性发作和免疫衰老性发作。老年特应性皮炎、老年湿疹以及迟发性或成人特应性皮炎或湿疹也可能属于 CEEA 的范畴,因为老年患者通常不符合特应性皮炎的严格标准。由于这种术语上的异质性,CEEA 没有标准化的检查算法。这种缺乏统一性可能会掩盖对这种疾病的适当治疗进行研究和理解的能力。然而,随着提供者对 CEEA 的认识不断提高,并且在为老年人做出这一诊断时更加舒适,皮肤科医生了解在该人群中使用常见 CEEA 治疗方法的安全性和疗效是必要的。在这里,我们讨论了治疗老年 CEEA 患者的局部和全身治疗的特殊考虑因素、挑战和建议。我们概述了治疗策略和潜在的治疗障碍,并讨论了在护理这一患者群体时共同决策的重要作用。

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