Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil.
Rev Paul Pediatr. 2023 Mar 13;41:e2021407. doi: 10.1590/1984-0462/2023/41/2021407. eCollection 2023.
The aim of this study was to identify clinical and complete blood count differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2 and compare the complete blood count of patients with sickle cell disease infected by SARS-CoV-2 before hospitalization and on admission.
This study was a single-center prospective cohort. Data were collected from medical records of pediatric inpatients with sickle cell disease under 18 years old infected or not with SARS-CoV-2 from the first visit to the hospital until discharge and from the last medical appointment. All patients were tested for SARS-CoV-2 by the real-time reverse transcription polymerase chain reaction.
Among 57 pediatric patients with sickle cell disease hospitalized from March to November 2020 in a Brazilian academic hospital, 11 (19.3%) had a positive result for SARS-CoV-2. Patients infected by SARS-CoV-2 had a higher prevalence of comorbidities than the ones who were not infected (63.6 vs. 30.4%; p=0.046). During hospital stay, no clinical or complete blood count differences between groups were found. There was a decrease in eosinophil count on hospital admission in patients with sickle cell disease infected by SARS-CoV-2 (p=0.008).
Pediatric hospitalized patients with sickle cell disease infected by SARS-CoV-2 had more comorbidities and had a decrease in eosinophil count between hospital admission and the last medical appointment.
本研究旨在确定感染和未感染 SARS-CoV-2 的住院儿童镰状细胞病患者之间的临床和全血细胞计数差异，并比较感染 SARS-CoV-2 的镰状细胞病患者在住院前和住院期间的全血细胞计数。
本研究为单中心前瞻性队列研究。数据来自巴西一家学术医院 2020 年 3 月至 11 月期间 18 岁以下住院镰状细胞病患儿的病历，采集内容为从首次就诊至出院以及最后一次就诊的所有信息。所有患者均通过实时逆转录聚合酶链反应检测 SARS-CoV-2。
在一家巴西学术医院住院的 57 名镰状细胞病患儿中，有 11 名（19.3%）SARS-CoV-2 检测结果为阳性。感染 SARS-CoV-2 的患者比未感染的患者合并症发生率更高（63.6%比 30.4%；p=0.046）。在住院期间，两组之间未发现临床或全血细胞计数差异。感染 SARS-CoV-2 的镰状细胞病患者在住院期间的嗜酸性粒细胞计数下降（p=0.008）。
感染 SARS-CoV-2 的住院儿童镰状细胞病患者合并症更多，且在住院期间和最后一次就诊期间的嗜酸性粒细胞计数下降。
