Yamaguchi Ryo, Katayama Osamu, Lee Sangyoon, Makino Keitaro, Harada Kenji, Morikawa Masanori, Tomida Kouki, Nishijima Chiharu, Fujii Kazuya, Misu Yuka, Shimada Hiroyuki
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan; Medical Science Division, Department of Medical Sciences, Graduate School of Medicine, Science and Technology, Shinshu University, Matsumoto, Nagano, Japan.
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan; Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo, Japan.
Arch Gerontol Geriatr. 2023 Jul;110:104988. doi: 10.1016/j.archger.2023.104988. Epub 2023 Mar 4.
Whether the combination of sarcopenia and systolic blood pressure (SBP) changes the risk of all-cause mortality is unknown. Thus, this study aimed to examine the association between sarcopenia and SBP in community-dwelling older adults and determine whether this association changes the mortality risk.
Older adults aged ≥65 years participated in the baseline assessment. The participants were classified into six groups according to a combination of the presence or absence of sarcopenia (sarcopenia, non-sarcopenia) and SBP (low SBP, ≤119 mmHg; normal SBP, 120-139 mmHg; high SBP, ≥140 mmHg). The participants were followed for the occurrence of death for 5 years after baseline assessment. Muscle mass, grip strength, and walking speed as indicators of sarcopenia, SBP, and all-cause mortality data for 5 years from baseline assessment were evaluated.
This study included 13,569 community-dwelling older adults. During the 5-year follow-up period, 830 participants (6.6%) died. In the Cox proportional hazards models, the risk of all-cause mortality was higher in other non-sarcopenia groups than in the non-sarcopenia/normal SBP group. In particular, those with sarcopenia had a higher mortality risk.
Low or high SBP increased the mortality risk in community-dwelling older adults. In those with sarcopenia, low or high SBP was associated with an even higher mortality risk. Older adults with sarcopenia and low/high blood pressure should be monitored as a population at a higher mortality risk.
肌肉减少症与收缩压（SBP）的组合是否会改变全因死亡率风险尚不清楚。因此，本研究旨在探讨社区居住的老年人中肌肉减少症与SBP之间的关联，并确定这种关联是否会改变死亡风险。
年龄≥65岁的老年人参与了基线评估。根据是否存在肌肉减少症（肌肉减少症、非肌肉减少症）和SBP（低SBP，≤119mmHg；正常SBP，120 - 139mmHg；高SBP，≥140mmHg）的组合，将参与者分为六组。在基线评估后对参与者进行了5年的死亡情况随访。评估了作为肌肉减少症指标的肌肉质量、握力和步行速度、SBP以及自基线评估起5年的全因死亡率数据。
本研究纳入了13569名社区居住的老年人。在5年的随访期内，830名参与者（6.6%）死亡。在Cox比例风险模型中，其他非肌肉减少症组的全因死亡风险高于非肌肉减少症/正常SBP组。特别是，患有肌肉减少症的人死亡风险更高。
低SBP或高SBP会增加社区居住老年人的死亡风险。在患有肌肉减少症的人群中，低SBP或高SBP与更高的死亡风险相关。患有肌肉减少症且血压低/高的老年人应作为死亡风险较高的人群进行监测。
