Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran; Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Eur J Pharmacol. 2023 May 5;946:175644. doi: 10.1016/j.ejphar.2023.175644. Epub 2023 Mar 14.
N6-methyladenosine (m6A) is the most widespread endogenous modification affecting the expression of eukaryotic mRNA transcripts. Recent studies have shown that the m6A marks within non-coding RNAs can affect their functions and expression in a manner similar to that of mRNA-coding genes. Since non-coding RNAs are involved in the pathophysiology of several disorders, identification of the role of m6A marks in the regulation of expression of non-coding RNAs can open a new era for identifying underlying mechanisms of several disorders and designing novel therapeutic modalities for a variety of disorders, particularly cancers. Moreover, a number of non-coding RNAs can affect m6A levels. In the current review, we discuss the impacts of m6A marks on the expression of non-coding RNAs in the context of different disorders, such as bone, gastrointestinal, neurologic, renal, pulmonary, hepatic and other disorders.
N6-甲基腺苷（m6A）是影响真核生物 mRNA 转录本表达的最广泛的内源性修饰。最近的研究表明，非编码 RNA 中的 m6A 标记可以以类似于 mRNA 编码基因的方式影响它们的功能和表达。由于非编码 RNA 参与多种疾病的病理生理学，鉴定 m6A 标记在非编码 RNA 表达调控中的作用可以为多种疾病（特别是癌症）的潜在机制的鉴定和新型治疗方法的设计开辟一个新时代。此外，一些非编码 RNA 可以影响 m6A 水平。在当前的综述中，我们讨论了 m6A 标记在不同疾病（如骨骼、胃肠道、神经、肾脏、肺部、肝脏和其他疾病）中非编码 RNA 表达中的影响。
