Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, China.
Department of Endocrinology, Tengzhou Central People's Hospital, Tengzhou, China.
Clin Exp Hypertens. 2023 Dec 31;45(1):2190529. doi: 10.1080/10641963.2023.2190529.
Hypertension is a chronic disease with multiple causative factors that involve metabolic disturbances and can cause various complications. However, the metabolic characteristics of hypertension at different stages are still unclear. This study aimed to explore the metabolic changes induced by hypertension at different ages.
Spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats were divided into four groups according to age: 5-week-old SHR ( = 6), 5-week-old WKY rats ( = 6), 32-week-old SHR ( = 6), and 32-week-old WKY rats ( = 6). Metabolites were analyzed in primary tissues (serum, heart, lung, kidney, brain, and brown adipose) using a non-targeted metabolomics approach.
Thirty-five metabolites and nine related metabolic pathways were identified in 5-week-old SHR, mainly related to the metabolism of amino acids. Fifty-one metabolites and seven related metabolic pathways were identified in the 32-week-old SHR, involving glycolysis, lipid, and amino acid metabolisms.
This experiment elucidates the metabolic profile of SHR at different ages and provides a basis for predicting and diagnosing hypertension. It also provides a reference for the pathogenesis of hypertension.
高血压是一种涉及代谢紊乱的慢性疾病，可引起多种并发症。然而，不同阶段高血压的代谢特征仍不清楚。本研究旨在探讨不同年龄高血压引起的代谢变化。
将自发性高血压大鼠（SHR）和 Wistar Kyoto（WKY）大鼠按年龄分为四组：5 周龄 SHR（n=6）、5 周龄 WKY 大鼠（n=6）、32 周龄 SHR（n=6）和 32 周龄 WKY 大鼠（n=6）。采用非靶向代谢组学方法分析血清、心脏、肺、肾、脑和棕色脂肪等主要组织中的代谢物。
在 5 周龄 SHR 中鉴定出 35 种代谢物和 9 种相关代谢途径，主要与氨基酸代谢有关。在 32 周龄 SHR 中鉴定出 51 种代谢物和 7 种相关代谢途径，涉及糖酵解、脂质和氨基酸代谢。
该实验阐明了不同年龄 SHR 的代谢特征，为预测和诊断高血压提供了依据，也为高血压的发病机制提供了参考。
