Adler G, Hausmann W, Elsebach K, Goke B, Lorenz-Meyer H, Herberg L, Arnold R
Dept of Internal Medicine, Philipps U. of Marburg, FRG
Gut. 1987;28 Suppl(Suppl):193-5. doi: 10.1136/gut.28.suppl.193.
Intestinal enzyme activities were investigated in mice with spontaneously occurring exocrine pancreatic insufficiency (EPI), in rats after induction of pancreatic insufficiency by intraductal injection of oleic acid, and in rats after feeding a proteinase inhibitor (Camostate) which induced a marked pancreatic hypertrophy. An increase in saccharase activity and in vitro uptake of L-phenylalanine was found in EPI mice, while activities of alkaline phosphatase and lactase were not altered. In oleic acid induced pancreatic insufficiency and in pancreatic hypertrophy no alterations in enzyme activities were observed. Morphometric analysis revealed no alterations in mucosal surface of EPI mice. It was suggested that the small intestine adapts fuctionally to severe and long lasting pancreatic insufficiency, but not to pancreatic hypertrophy.
对患有自发性外分泌性胰腺功能不全(EPI)的小鼠、经导管注射油酸诱导胰腺功能不全后的大鼠以及喂食蛋白酶抑制剂(卡莫司他)诱导胰腺显著肥大后的大鼠的肠道酶活性进行了研究。在EPI小鼠中发现蔗糖酶活性增加以及L-苯丙氨酸的体外摄取增加,而碱性磷酸酶和乳糖酶的活性未改变。在油酸诱导的胰腺功能不全和胰腺肥大中,未观察到酶活性的改变。形态计量分析显示EPI小鼠的黏膜表面没有变化。研究表明,小肠在功能上适应严重且持久的胰腺功能不全,但不适应胰腺肥大。