Hasegawa Naomi, Rusakevich Alexander, Bernicker Eric, Teh Bin S, Schefler Amy
aDepartment of Ophthalmology, University of Texas at Houston, Houston, Texas, USA.
bRetina Consultants of Texas, Houston, Texas, USA.
Ocul Oncol Pathol. 2022 Nov;8(3):156-160. doi: 10.1159/000524918. Epub 2022 May 9.
The aim of this study was to compare the clinical and gene expression variables of uveal melanoma patients presenting before and after the start of the COVID-19 pandemic as surrogate markers in order to assess the pandemic's potential impact on care. We conducted a retrospective chart review of uveal melanoma patients at Retina Consultants of Texas and assessed tumor size, staging, and gene expression data during two time periods: May 2019 to February 2020 (Group 1: Before the COVID-19 pandemic declaration by the WHO in March 2020) and May 2020 to March 2021 (Group 2: After the start of the COVID-19 pandemic). A total of 80 patients with uveal melanoma were studied (Group 1: 40 [50%] and Group 2: 40 [50%]). There was no statistically significant difference in the tumor thickness ( = 0.768), largest base dimension ( = 0.758), Collaborative Ocular Melanoma Study size class ( = 0.762), and American Joint Committee on Cancer stages ( = 0.872) between the two groups. Additionally, there was no difference in the tumors' gene expression data including gene expression profile class ( = 0.587) and PRAME expressivity ( = 0.861) between the two groups. The COVID-19 pandemic had no effect on the presentation of uveal melanoma patients across all tumor characteristics including size, staging, and gene expression data, suggesting there was not a significant diagnostic delay in care for uveal melanoma patients at our center due to the pandemic.
本研究的目的是比较在2019冠状病毒病大流行开始之前和之后就诊的葡萄膜黑色素瘤患者的临床和基因表达变量，作为替代标志物，以评估大流行对医疗护理的潜在影响。我们对德克萨斯视网膜咨询公司的葡萄膜黑色素瘤患者进行了回顾性病历审查，并评估了两个时间段内的肿瘤大小、分期和基因表达数据：2019年5月至2020年2月（第1组：在世界卫生组织于2020年3月宣布2019冠状病毒病大流行之前）和2020年5月至2021年3月（第2组：在2019冠状病毒病大流行开始之后）。共研究了80例葡萄膜黑色素瘤患者（第1组：40例[50%]，第2组：40例[50%]）。两组之间的肿瘤厚度（P = 0.768）、最大基底尺寸（P = 0.758）、协作性眼黑色素瘤研究大小类别（P = 0.762）和美国癌症联合委员会分期（P = 0.872）无统计学显著差异。此外，两组之间肿瘤的基因表达数据也无差异，包括基因表达谱类别（P = 0.587）和PRAME表达性（P = 0.861）。2019冠状病毒病大流行对葡萄膜黑色素瘤患者的所有肿瘤特征（包括大小、分期和基因表达数据）的表现均无影响，这表明在我们中心，由于大流行，葡萄膜黑色素瘤患者的护理没有出现显著的诊断延迟。
