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"Not Valproic Acid" Is Not Without Risk: In Utero Exposure to Topiramate Is Associated With an Increased Risk of Neurodevelopmental Disorders.

作者信息

Gerard Elizabeth E

机构信息

Department of Neurology, Feinberg School of Medicine.

出版信息

Epilepsy Curr. 2022 Nov 1;23(1):14-17. doi: 10.1177/15357597221130878. eCollection 2023 Jan-Feb.

DOI:10.1177/15357597221130878
PMID:36923329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10009118/
Abstract
摘要

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"Not Valproic Acid" Is Not Without Risk: In Utero Exposure to Topiramate Is Associated With an Increased Risk of Neurodevelopmental Disorders.“非丙戊酸”并非没有风险：子宫内接触托吡酯与神经发育障碍风险增加有关。
Epilepsy Curr. 2022 Nov 1;23(1):14-17. doi: 10.1177/15357597221130878. eCollection 2023 Jan-Feb.
2
Adjunctive topiramate enhances the risk of hypothermia associated with valproic acid therapy.辅助使用托吡酯会增加与丙戊酸治疗相关的体温过低风险。
J Clin Pharm Ther. 2008 Oct;33(5):513-9. doi: 10.1111/j.1365-2710.2008.00943.x.
3
Topiramate-Related Hyperammonemia.托吡酯相关的高氨血症
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5
Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study.与妊娠期间最常使用的抗癫痫药物相关的产前暴露的早期神经发育结局风险：一项法国全国基于人群的队列研究。
BMJ Open. 2020 Jun 7;10(6):e034829. doi: 10.1136/bmjopen-2019-034829.
6
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本文引用的文献

1
Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability.产前暴露于抗癫痫药物与自闭症和智力残疾风险的关联。
JAMA Neurol. 2022 Jul 1;79(7):672-681. doi: 10.1001/jamaneurol.2022.1269.
2
Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France.与子宫内暴露于丙戊酸和其他抗癫痫药物相关的早期神经发育障碍风险：法国全国队列研究。
Sci Rep. 2020 Oct 22;10(1):17362. doi: 10.1038/s41598-020-74409-x.
3
Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study.抗癫痫药物宫内暴露对 5 岁和 8 岁儿童语言障碍的影响——挪威母婴队列研究。
Eur J Neurol. 2020 Apr;27(4):667-675. doi: 10.1111/ene.14140. Epub 2019 Dec 30.
4
In utero exposure to antiepileptic drugs is associated with learning disabilities among offspring.胎儿暴露于抗癫痫药物与后代学习障碍有关。
J Neurol Neurosurg Psychiatry. 2018 Dec;89(12):1324-1331. doi: 10.1136/jnnp-2018-318386. Epub 2018 Aug 3.
5
Topiramate use early in pregnancy and the risk of oral clefts: A pregnancy cohort study.孕期早期使用托吡酯与口腔裂的风险：一项妊娠队列研究。
Neurology. 2018 Jan 23;90(4):e342-e351. doi: 10.1212/WNL.0000000000004857. Epub 2017 Dec 27.
6
Fetal growth and premature delivery in pregnant women on antiepileptic drugs.抗癫痫药物对孕妇胎儿生长和早产的影响。
Ann Neurol. 2017 Sep;82(3):457-465. doi: 10.1002/ana.25031.
7
Cognition in school-age children exposed to levetiracetam, topiramate, or sodium valproate.学龄儿童使用左乙拉西坦、托吡酯或丙戊酸钠后的认知情况。
Neurology. 2016 Nov 1;87(18):1943-1953. doi: 10.1212/WNL.0000000000003157. Epub 2016 Aug 31.
8
Antiepileptic drug combinations not involving valproate and the risk of fetal malformations.不涉及丙戊酸盐的抗癫痫药物联合使用与胎儿畸形风险
Epilepsia. 2016 Jul;57(7):1048-52. doi: 10.1111/epi.13415. Epub 2016 Jun 5.
9
Dose-dependent teratogenicity of valproate in mono- and polytherapy: an observational study.丙戊酸盐单药及联合治疗的剂量依赖性致畸作用：一项观察性研究
Neurology. 2015 Sep 8;85(10):866-72. doi: 10.1212/WNL.0000000000001772. Epub 2015 Jun 17.
10
Preliminary findings of the developmental effects of in utero exposure to topiramate.胎儿暴露于托吡酯的发育影响的初步研究结果。
Reprod Toxicol. 2012 Nov;34(3):308-11. doi: 10.1016/j.reprotox.2012.05.038. Epub 2012 May 30.