Sex on the Brain: Reproductive Comorbidities in Temporal Lobe Epilepsy.
作者信息
Carpenter Jenna C, Lignani Gabriele
机构信息
Department of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, University College London, London.
出版信息
Epilepsy Curr. 2022 Nov 29;23(1):58-60. doi: 10.1177/15357597221135717. eCollection 2023 Jan-Feb.
Abstract
摘要
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本文引用的文献
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Increased GABA transmission to GnRH neurons after intrahippocampal kainic acid injection in mice is sex-specific and associated with estrous cycle disruption.在小鼠海马内注射海人酸后，GABA 向 GnRH 神经元的传递增加具有性别特异性，并与动情周期紊乱有关。
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Epilepsy-associated increase in gonadotropin-releasing hormone neuron firing in diestrous female mice is independent of chronic seizure burden severity.发情期雌性小鼠中与癫痫相关的促性腺激素释放激素神经元放电增加与慢性癫痫发作负担严重程度无关。
Epilepsy Res. 2022 Aug;184:106948. doi: 10.1016/j.eplepsyres.2022.106948. Epub 2022 May 20.
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Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice.基于内侧海马注射海人酸致痫的女性小鼠偏侧化的表型差异。
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4
The Kainic Acid Models of Temporal Lobe Epilepsy.颞叶癫痫的 kainic 酸模型
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In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy.体内 CRISPRa 减少癫痫啮齿动物模型中的癫痫发作并挽救认知缺陷。
Brain. 2020 Mar 1;143(3):891-905. doi: 10.1093/brain/awaa045.
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Dynamic and Sex-Specific Changes in Gonadotropin-Releasing Hormone Neuron Activity and Excitability in a Mouse Model of Temporal Lobe Epilepsy.颞叶癫痫小鼠模型中促性腺激素释放激素神经元活动和兴奋性的动态和性别特异性变化。
eNeuro. 2018 Sep 24;5(5). doi: 10.1523/ENEURO.0273-18.2018. eCollection 2018 Sep-Oct.
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Neurol Clin. 2009 Nov;27(4):941-965. doi: 10.1016/j.ncl.2009.08.005.
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Disorders of reproduction in patients with epilepsy: primary neurological mechanisms.癫痫患者的生殖系统紊乱：主要神经机制。
Seizure. 2008 Mar;17(2):101-10. doi: 10.1016/j.seizure.2007.11.025. Epub 2007 Dec 31.
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