多态性与强迫症风险之间的关联。
Association between polymorphisms and risk of obsessive-compulsive disorder.
作者信息
Akbari Mohammadarian, Hussen Bashdar Mahmud, Eslami Solat, Neishabouri Seyedeh Morvarid, Ghafouri-Fard Soudeh
机构信息
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq.
出版信息
Heliyon. 2023 Feb 25;9(3):e14081. doi: 10.1016/j.heliyon.2023.e14081. eCollection 2023 Mar.
Obsessive-compulsive disorder (OCD) is a disorder in which genetic factors participate. ANRIL is an example of long non-coding RNAs with crucial roles in the pathoetiology of multifactorial disorders, including neuropsychiatric conditions. We appraised association between rs1333045, rs1333048, rs10757278 and rs4977574 polymorphisms and OCD in Iranian population. There were no remarkable differences in allele and genotype distribution of rs1333045, rs1333048, rs4977574, and rs10757278 between OCD Patients and normal controls. However, the CCGG haplotype (equivalent to rs1333045, rs1333048, rs4977574 and rs10757278, respectively) has been shown to decrease risk of OCD (OR (95% CI) = 0.57 (0.39-0.85), P value-0.006 and FDR q-value = 0.041). On the other hand, TCGA haplotype has been found as a risk haplotype for OCD (OR (95% CI) = 5.17 (1.44-18.55), P value = 0.005 and FDR q-value = 0.041). In brief, the current study indicates association between two ANRIL haplotypes and risk of OCD in Iranian people.
强迫症（OCD）是一种有遗传因素参与的疾病。ANRIL是长链非编码RNA的一个例子，在包括神经精神疾病在内的多因素疾病的病理病因中起关键作用。我们评估了rs1333045、rs1333048、rs10757278和rs4977574多态性与伊朗人群强迫症之间的关联。强迫症患者与正常对照组在rs1333045、rs1333048、rs4977574和rs10757278的等位基因和基因型分布上没有显著差异。然而，CCGG单倍型（分别相当于rs1333045、rs1333048、rs4977574和rs10757278）已被证明可降低患强迫症的风险（OR（95%CI）=0.57（0.39 - 0.85），P值 = 0.006，FDR q值 = 0.041）。另一方面，TCGA单倍型已被发现是强迫症的风险单倍型（OR（95%CI）=5.17（1.44 - 18.55），P值 = 0.005，FDR q值 = 0.041）。简而言之，当前研究表明两种ANRIL单倍型与伊朗人群患强迫症的风险之间存在关联。
Zotero 插件