长链非编码RNA（lncRNAs）与多态性和宫颈癌的关联
Association of Long Non-Coding RNAs (lncRNAs) and Polymorphism with Cervical Cancer.
作者信息
Yao Yueting, Liang Yan, Dong Xudong, Liu Shuyuan, Zhang Shao, Liu Weipeng, Li Yu, Shi Li, Yan Zhiling, Yao Yufeng
机构信息
Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, 650118, People's Republic of China.
College of Nursing Health Sciences, Yunnan Open University, Kunming, 650223, People's Republic of China.
出版信息
Pharmgenomics Pers Med. 2022 Apr 21;15:359-375. doi: 10.2147/PGPM.S358453. eCollection 2022.
BACKGROUND
Long non-coding RNAs (lncRNAs) and their polymorphisms play crucial roles in the development of different cancers.
METHODS
Eight single-nucleotide polymorphisms (SNPs) in and (rs1333045, rs4977574, rs1333048, and rs10757278 in and rs11227209, rs619586, rs664589, and rs3200401 in ) were enrolled and genotyped in a total of 1248 samples, including 587 patients with cervical cancer (CC) and 661 healthy individuals using in TaqMan assay. The association of these SNPs with CC was then evaluated.
RESULTS
Our results showed that the allele and genotype frequencies of rs3200401 in were significantly different between the control and CC groups after Bonferroni correction ( = 0.001 and = 0.004, respectively), indicating that the C allele is a protective factor against CC (OR = 0.70; 95% CI = 0.57-0.87). In addition, the allele and genotype frequencies of rs4977574 in were significantly different between the control and CC groups after Bonferroni correction ( = 0.004 and = 0.014, respectively), and the A allele might be a protective factor for CC (OR = 0.80; 95% CI = 0.68-0.93). For subgroup analysis, the alleles of rs3200401 in showed significant differences between the control and adenocarcinoma (AC) and control and squamous cell carcinoma (SCC) groups ( = 0.005 and = 0.004, respectively). The rs3200401C allele could be a protective factor for AC and SCC development (OR = 0.57; 95% CI = 0.38-0.85; OR = 0.72; 95% CI = 0.58-0.90). Moreover, the rs3200401C allele could be a protective factor for cervical cancer stage I development (OR = 0.67; 95% CI = 0.53-0.86).
CONCLUSION
Our results indicate that rs3200401 in and rs4977574 in could play key roles in the CC development.
背景
长链非编码RNA（lncRNAs）及其多态性在不同癌症的发生发展中起关键作用。
方法
纳入了位于 和 上的8个单核苷酸多态性（SNP）（ 上的rs1333045、rs4977574、rs1333048和rs10757278， 上的rs11227209、rs619586、rs664589和rs3200401），并使用TaqMan分析法对总共1248个样本进行基因分型，其中包括587例宫颈癌（CC）患者和661名健康个体。然后评估这些SNP与CC的相关性。
结果
我们的结果显示，经Bonferroni校正后，对照组与CC组之间 上rs3200401的等位基因和基因型频率存在显著差异（分别为 = 0.001和 = 0.004），表明C等位基因是预防CC的保护因素（OR = 0.70；95% CI = 0.57 - 0.87）。此外，经Bonferroni校正后，对照组与CC组之间 上rs4977574的等位基因和基因型频率也存在显著差异（分别为 = 0.004和 = 0.014），A等位基因可能是CC的保护因素（OR = 0.80；95% CI = 0.68 - 0.93）。亚组分析显示， 上rs3200401的等位基因在对照组与腺癌（AC）组以及对照组与鳞状细胞癌（SCC）组之间存在显著差异（分别为 = 0.005和 = 0.004）。rs3200401C等位基因可能是AC和SCC发生发展的保护因素（OR = 0.57；95% CI = 0.38 - 0.85；OR = 0.72；95% CI = 0.58 - 0.90）。此外，rs3200401C等位基因可能是宫颈癌I期发生发展的保护因素（OR = 0.67；95% CI = 0.53 - 0.86）。
结论
我们的结果表明， 上的rs3200401和 上的rs4977574可能在CC的发生发展中起关键作用。
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