Hao Meng-Ying, Zhang Yin, Lin Na, Fu Rong, Ji Xiao-Shuang, Jiang Bo, Tu Shu-Jiang, Hao Wen-Juan
School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou, 221116, P. R. China.
School of Pharmacy, Zhengzhou Vocational College of Medicine and Health, Zhengzhou 452385, P. R. China.
Chem Commun (Camb). 2023 Mar 30;59(27):4032-4035. doi: 10.1039/d3cc00089c.
A new gold(I) self-relay catalysis reaction enabling the annulative oxygenation of propargylic alcohols with various O-nucleophiles, such as carboxylic acids, alcohols and TBHP, is reported, producing a series of functionalized benzofurans in moderate to good yields under mild conditions. This protocol benefits from the π- and σ-Lewis acid capability of gold complexes, demonstrating high molecular convergence, broad substrate flexibility, high functional group compatibility and mild conditions.
报道了一种新型的金（I）自中继催化反应，该反应能使炔丙醇与各种O-亲核试剂（如羧酸、醇和叔丁基过氧化氢）发生环化氧化反应，在温和条件下以中等至良好的产率生成一系列功能化苯并呋喃。该方法得益于金配合物的π-和σ-路易斯酸能力，具有高分子收敛性、广泛的底物灵活性、高官能团兼容性和温和的反应条件。
