Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Cancer Med. 2023 Jun;12(12):13675-13686. doi: 10.1002/cam4.5987. Epub 2023 May 6.
Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries, with overall incidence increasing, particularly high-grade disease. There is sparse information regarding quality of life (QOL) in EC survivors with a focus on grade of disease.
A total of 259 women with EC diagnosed between 2016 and 2020 were identified via the Metropolitan Detroit Cancer Surveillance System and consented to enroll in the Detroit Research on Cancer Survivors cohort study (if African American, n = 138) or completed the baseline interview (if non-Hispanic white, n = 121). Each respondent provided information about their health history, educational attainment, health behaviors, and demographics. The Functional Assessment of Cancer Therapy-General (FACT-G) and Endometrial-specific (FACT-En) were used to assess QOL.
Women diagnosed with high-grade (n = 112) and low-grade (n = 147) EC participated in this study. EC survivors with high-grade disease reported significantly lower QOL compared to survivors with low-grade disease (85 vs. 91, respectively, p value = 0.025) as assessed by the FACT-G. This difference was driven by lower physical and functional subscales among women with high-grade disease compared to those with low-grade disease (p value = 0.016 and p = 0.028, respectively). Interestingly, EC-specific QOL measures, as assessed by the FACT-En, did not differ by grade.
Grade of disease impacts QOL in EC survivors, as well as socioeconomic, psychological, and physical factors. Most of these factors are amenable to interventions and should be assessed in patients after an EC diagnosis.
子宫内膜癌（EC）是发达国家最常见的妇科恶性肿瘤，总体发病率呈上升趋势，尤其是高级别疾病。关于疾病分级的 EC 幸存者生活质量（QOL）的信息很少。
通过底特律癌症监测系统确定了 2016 年至 2020 年间诊断为 EC 的 259 名女性，并同意参加底特律癌症幸存者研究队列研究（如果是非裔美国人，n=138）或完成基线访谈（如果是非西班牙裔白人，n=121）。每位受访者提供有关其健康史、教育程度、健康行为和人口统计学的信息。使用癌症治疗功能评估一般量表（FACT-G）和子宫内膜特定量表（FACT-En）评估 QOL。
患有高级别（n=112）和低级别（n=147）EC 的女性参与了这项研究。高级别 EC 幸存者的 QOL 明显低于低级别 EC 幸存者（分别为 85 和 91，p 值=0.025），这是由高级别疾病女性的身体和功能子量表比低级别疾病女性低造成的（p 值分别为 0.016 和 0.028）。有趣的是，FACT-En 评估的 EC 特异性 QOL 测量值与分级无关。
疾病分级会影响 EC 幸存者的 QOL，以及社会经济、心理和身体因素。这些因素中的大多数都可以通过干预来改善，并且应该在 EC 诊断后对患者进行评估。
