Yang Xi, Fridman Andrew J, Unsworth Nash, Casement Melynda D
Department of Psychology, University of Oregon, 1451 Onyx St, Eugene, OR US 97403, USA.
Neurosci Biobehav Rev. 2023 May;148:105125. doi: 10.1016/j.neubiorev.2023.105125. Epub 2023 Mar 15.
Elaborative affective processing is observed in depression, and pupillary reactivity, a continuous, sensitive, and reliable indicator of physiological arousal and neurocognitive processing, is increasingly utilized in studies of depression-related characteristics. As a first attempt to quantitively summarize existing evidence on depression-related pupillary reactivity alterations, this review and meta-analysis evaluated the direction, magnitude, and specificity of pupillary indices of affective processing towards positively, negatively, and neutrally-valenced stimuli among individuals diagnosed with depression or with elevated risk of depression. Studies on pupillary responses to affective stimuli in the target groups were identified in PsycINFO and PubMed databases. Twenty-two articles met inclusion criteria for the qualitative review and 16 for the quantitative review. Three-level frequentist and Bayesian models were applied to summarize pooled effects from baseline-controlled stimuli-induced average changes in pupillary responses. In general, compared to non-depressed individuals, individuals with depression or elevated risk of depression exhibited higher pupillary reactivity (d =0.15) towards negatively-valenced stimuli during affective processing. Pupillary motility towards negatively-valenced stimuli may be a promising trait-like marker for depression vulnerability.
在抑郁症中可观察到精细情感加工，而瞳孔反应性作为生理唤醒和神经认知加工的连续、敏感且可靠的指标，在抑郁症相关特征的研究中越来越多地被使用。作为首次定量总结关于抑郁症相关瞳孔反应性改变的现有证据的尝试，本综述和荟萃分析评估了在被诊断为抑郁症或有抑郁症高风险的个体中，情感加工的瞳孔指标对正性、负性和中性效价刺激的反应方向、幅度和特异性。在PsycINFO和PubMed数据库中检索了关于目标群体对情感刺激的瞳孔反应的研究。22篇文章符合定性综述的纳入标准，16篇符合定量综述的纳入标准。应用三级频率主义模型和贝叶斯模型来总结基线对照刺激诱发的瞳孔反应平均变化的合并效应。总体而言，与非抑郁症个体相比，抑郁症患者或有抑郁症高风险的个体在情感加工过程中对负性效价刺激表现出更高的瞳孔反应性（d=0.15）。对负性效价刺激的瞳孔活动可能是抑郁症易感性的一个有前景的特质样标志物。
