Orthopedics department, Hôpital Cochin Paris, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Hôpital Lariboisière, Paris, France.
Orthop Traumatol Surg Res. 2023 Oct;109(6):103596. doi: 10.1016/j.otsr.2023.103596. Epub 2023 Mar 14.
In France, prescribing pregabalin requires a secure prescription valid for 6 months since the decree of 12 February 2021, based on recommendations of the French Centre for Evaluation and Information on Pharmacodependence and Addiction vigilance (CEIP-A). This led to discontinuation of this treatment as a postoperative analgesic in the French ACL Study (FAST) cohort. We aimed to evaluate the impact of this change on early postoperative pain.
Pregabalin is an important analgesic for reducing early postoperative pain after anterior cruciate ligament (ACL) repair.
At our healthcare facility, 584 patients from the FAST cohort who underwent primary isolated ACL reconstruction were included: 292 patients operated before June 1, 2021 who received pregabalin postoperatively and 292 patients operated after June 1, 2021 who did not receive pregabalin. The patients were matched based on age, sex, preoperative Lysholm and Tegner scores. Pain was evaluated on a visual analog scale (VAS) on D0 in the evening, D0 at night, D1, D2 and D3.
The patients who did not receive pregabalin had more severe pain at night on D0: 5.21 vs 5.68 (p=.048). There was no difference between groups in the postoperative pain at rest during the evening of D0 (p=.89), D1 (p=.33), D2 (p=.37) and D3 (p=.21).
In the context of outpatient arthroscopic ACL reconstruction, pregabalin does not reduce early postoperative pain in a clinically significant manner.
IV; case-control study.
自 2021 年 2 月 12 日的法令以来，在法国，开具普瑞巴林需要开具有效期为 6 个月的安全处方，这是基于法国评估和信息中心（CEIP-A）对药物依赖和成瘾警戒的建议。这导致 pregabalin 作为法国 ACL 研究（FAST）队列的术后镇痛药物被停用。我们旨在评估这一变化对早期术后疼痛的影响。
普瑞巴林是一种重要的镇痛药物，可减轻前交叉韧带（ACL）修复后的早期术后疼痛。
在我们的医疗机构中，纳入了 FAST 队列中的 584 名接受初次孤立性 ACL 重建的患者：292 名于 2021 年 6 月 1 日前接受手术的患者术后接受 pregabalin 治疗，292 名于 2021 年 6 月 1 日后接受手术的患者未接受 pregabalin 治疗。患者根据年龄、性别、术前 Lysholm 和 Tegner 评分进行匹配。疼痛通过视觉模拟评分（VAS）在 D0 晚上、D0 夜间、D1、D2 和 D3 进行评估。
未接受 pregabalin 治疗的患者在 D0 夜间疼痛更严重：5.21 对 5.68（p=.048）。两组患者在 D0 晚上休息时的术后疼痛无差异（p=.89）、D1（p=.33）、D2（p=.37）和 D3（p=.21）。
在关节镜下 ACL 重建的门诊环境中，普瑞巴林不能以临床显著的方式减轻早期术后疼痛。
IV；病例对照研究。
