Shi Q, Chen C, Lyu G B
Department of Spine Surgery, the Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410004, China.
Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhonghua Yi Xue Za Zhi. 2023 Mar 21;103(11):787-792. doi: 10.3760/cma.j.cn112137-20220915-01959.
Under the rapid development of national health and fitness, the incidence rates of bone-tendon injuries have been increasing observably. Bone-to-tendon healing poses a formidable clinical challenge due to the complex structure, composition and mechanics of the interface. A variety of strategies, including advanced biomaterials, bioactive growth factors and multiple stem cell lineages, have been developed, providing new adjuvant therapies for the repair of motor system injuries. Among them, tissue engineering of decellularized extracellular matrix materials is one of the most promising approaches. The well-designed shapes of scaffolds, the improvements of acellular protocols, the bioactivity enhancement of materials and the appropriate seed cells in biomimetic applications have been proved to have more satisfactory clinical efficacy and application prospects. This review intends to provide a reference for future innovations in bone-tendon injury by summarizing the research progresses of tissue engineering strategies in recent years.
在全民健身事业快速发展的背景下，骨腱损伤的发病率显著上升。由于界面结构、组成和力学的复杂性，骨与腱的愈合面临着严峻的临床挑战。人们已经开发了多种策略，包括先进的生物材料、生物活性生长因子和多种干细胞谱系，为运动系统损伤的修复提供了新的辅助治疗方法。其中，脱细胞细胞外基质材料的组织工程是最有前景的方法之一。支架的精心设计形状、脱细胞方案的改进、材料生物活性的增强以及仿生应用中合适的种子细胞，已被证明具有更令人满意的临床疗效和应用前景。本文综述旨在通过总结近年来组织工程策略的研究进展，为未来骨腱损伤的创新提供参考。
