Song Tianyi, Guo Lin, Wang Changcheng, Li Mingcheng
Second Department of Orthopedics, Affiliated Zhongshan Hospital, Dalian University, Dalian, Liaoning, 116001, People's Republic of China.
Department of Biomedical Engineering, School of Biomedical Engineering, Dalian University of Technology, Dalian, Liaoning, 116001, People's Republic of China.
Orthop Res Rev. 2025 Mar 6;17:105-113. doi: 10.2147/ORR.S501260. eCollection 2025.
Tendon healing after ligament or tendon reconstruction remains a significant challenge. Regenerative tissue engineering, an interdisciplinary field that combines biology, materials science, and engineering, offers promising solutions. Recent developments have introduced scaffold materials designed to enhance the proliferation and differentiation of tendon-to-bone tissue cells. These scaffolds possessing three-dimensional composites of tissue cells and biomaterials, have proven effective in facilitating tendon-to-bone curing post-surgery. The successful development of the tendon-to-bone interface is a critical factor for early rehabilitation and functional recovery. In this mini-review, we present a comprehensive update on contemporary strategies for synthetic scaffold-based materials and their influence on tendon-to-bone healing. We described the synthetic materials compositions, structures and features of single-layer, multi-layer, and gradient scaffolds with their special mechanical properties. We examined the construction of engineering scaffolds from the perspectives of biomaterials and design strategies, providing a comprehensive evaluation of the advantages and disadvantages associated with each approach. Ultimately, this review articulates clear research directions aimed at achieving breakthroughs in future studies.
韧带或肌腱重建后的肌腱愈合仍然是一项重大挑战。再生组织工程是一个将生物学、材料科学和工程学结合的跨学科领域，提供了有前景的解决方案。最近的进展引入了旨在促进肌腱-骨组织细胞增殖和分化的支架材料。这些拥有组织细胞和生物材料三维复合材料的支架，已被证明在促进术后肌腱-骨愈合方面有效。肌腱-骨界面的成功发育是早期康复和功能恢复的关键因素。在本综述中，我们全面更新了基于合成支架材料的当代策略及其对肌腱-骨愈合的影响。我们描述了具有特殊力学性能的单层、多层和梯度支架的合成材料组成、结构和特征。我们从生物材料和设计策略的角度研究了工程支架的构建，对每种方法的优缺点进行了全面评估。最终，本综述阐明了旨在在未来研究中取得突破的明确研究方向。
