Division of General Obstetrics and Gynecology, Department of Obstetrics & Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.
Division of General Obstetrics and Gynecology, Department of Obstetrics & Gynecology, Mackay Memorial Hospital, Taipei, Taiwan; MacKay Junior College of Medicine, Nursing and Management, New Taipei City, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
J Formos Med Assoc. 2023 Jul;122(7):557-563. doi: 10.1016/j.jfma.2023.02.004. Epub 2023 Mar 14.
The level of vitamin D in pregnant women and the effect of vitamin D supplementation are lack in Taiwan.
To investigate the vitamin D serum level and the effect of its supplementation on pregnancy.
We included 1048 pregnant women who underwent prenatal exam with known serum 25-hydroxyvitamin D3 [25(OH)D3] levels and delivery at the Mackay Memorial Hospital, Taipei, Taiwan during 2015-2018. A daily dose 2000 IU of vitamin D was given, starting at 12-16 weeks of pregnancy, to reach the level of 20 ng/mL, and then a maintenance dose of 800 IU/day was given. The other 3654 women without vitamin D supplementation delivered in 2018 served as control group. Pregnancy outcomes were recorded for analysis.
Over 80% of the 1048 pregnant women were vitamin D deficiency. There was an inverse correlation between serum vitamin D levels and maternal body mass index (p = 0.0366). We compared 375 women with serum vitamin D levels increased above 30 ng/mL after supplementation with control group. The rates of preterm birth, low birth weight, and postpartum hemorrhage between these 2 groups were 6.67% vs. 11.19% (p = 0.007), 6.40% vs. 10.0% (p = 0.025), and 1.33% vs. 3.20% (p = 0.04), respectively.
Vitamin D deficiency is very prevalent in pregnant women, especially those with high BMI, in Taiwan. It can be corrected by adequate vitamin D supplementation, which may decrease the risk of pregnancy complications and bring benefits to the fetus.
台湾孕妇的维生素 D 水平和维生素 D 补充效果缺乏。
调查维生素 D 血清水平及其对妊娠的影响。
我们纳入了 2015 年至 2018 年在台北马偕纪念医院进行产前检查并已知血清 25-羟维生素 D3 [25(OH)D3] 水平和分娩的 1048 名孕妇。从妊娠 12-16 周开始，每天给予 2000IU 的维生素 D 剂量，以达到 20ng/mL 的水平，然后给予 800IU/天的维持剂量。2018 年未补充维生素 D 的另外 3654 名孕妇作为对照组。记录妊娠结局进行分析。
超过 80%的 1048 名孕妇存在维生素 D 缺乏。血清维生素 D 水平与母体体重指数呈负相关（p=0.0366）。我们将 375 名血清维生素 D 水平增加到补充后 30ng/mL 以上的女性与对照组进行比较。两组早产儿、低体重儿和产后出血的发生率分别为 6.67%比 11.19%（p=0.007）、6.40%比 10.0%（p=0.025）和 1.33%比 3.20%（p=0.04）。
维生素 D 缺乏在台湾孕妇中非常普遍，尤其是那些 BMI 较高的孕妇。通过适当的维生素 D 补充可以纠正，这可能降低妊娠并发症的风险并为胎儿带来益处。
