前列环素（PGI2）对乌头碱诱发大鼠心律失常的抗心律失常作用。
The antiarrhythmic action of prostacyclin (PGI2) on aconitine induced arrhythmias in rats.
作者信息
Mest H J, Förster W
出版信息
Acta Biol Med Ger. 1978;37(5-6):827-8.
PMID:369259
Abstract
Prostacyclin (PGI2) produces an antiarrhythmic effect on aconitine induced arrhythmias in rats. The ED50 of PGI2 was 0.7 microgram/kg and the maximum antiarrhythmic effect 54 per cent. The equi-effective doses of PGE2 and PGF2alpha were higher (ED50 of PGF2alpha = 1.2 microgram/kg, ED50 of PGE2 = 2.7 microgram/kg). However, PGF2alpha and PGE2 had a maximum antiarrhythmic effect of 80 per cent in this model.
摘要
前列环素（PGI2）对乌头碱诱发的大鼠心律失常具有抗心律失常作用。PGI2的半数有效量（ED50）为0.7微克/千克，最大抗心律失常作用为54%。前列腺素E2（PGE2）和前列腺素F2α（PGF2α）的等效剂量更高（PGF2α的ED50 = 1.2微克/千克，PGE2的ED50 = 2.7微克/千克）。然而，在该模型中，PGF2α和PGE2的最大抗心律失常作用为80%。
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