前列腺素I2、E2和F2α对乌头碱诱导的大鼠心律失常的中枢神经作用。
The central nervous effect of prostaglandins I2, E2 and F2 alpha on aconitine-induced cardiac arrhythmia in rats.
作者信息
Mest H J, Förster W
出版信息
Prostaglandins. 1979 Aug;18(2):235-9. doi: 10.1016/0090-6980(79)90108-4.
PMID:392624
Abstract
Intracerebroventricular administration of PGI2 or PGE2 reduced aconitine-induced cardiac arrhythmia in rats. PGF2 alpha had no antiarrhythmic effect under the same conditions. The ED50 values of PGI2 and E2 were 0.25 microgram/kg and 1.1 microgram/kg, respectively. Central mechanisms may participate in the antiarrhythmic effect of these PGs.
摘要
脑室内注射前列环素（PGI2）或前列腺素E2（PGE2）可减轻乌头碱诱导的大鼠心律失常。在相同条件下，前列腺素F2α（PGF2α）没有抗心律失常作用。PGI2和PGE2的半数有效量（ED50）分别为0.25微克/千克和1.1微克/千克。中枢机制可能参与了这些前列腺素的抗心律失常作用。
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