Feng Jian-Yang, Jiang Qing-Ping, He Hong
Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, Guangdong Province, China.
Department of Pathology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, Guangdong Province, China.
World J Clin Cases. 2023 Feb 26;11(6):1365-1371. doi: 10.12998/wjcc.v11.i6.1365.
Endometriosis is a common gynecological disorder that affects women of reproductive age. It is characterized by a cancer-like invasion of the extra-uterine endometrium and exhibits a strong association with ovarian clear cell cancer and endometrioid cancer. Endometriosis-associated fallopian tube endometrioid adenocarcinoma synchronized with endometrial adenocarcinoma was rarely reported.
A 49-year-old woman was referred to our hospital complaining about abnormal vaginal bleeding for three years following unsatisfactory medication. Intraoperative frozen sections unexpectedly unveiled an endometrioid cancer of the left fallopian tube with superficial invasion surrounded by diffuse endometriosis synchronized with endometrioid endometrial cancer.
It was difficult to make a differential diagnosis when confronted with incidental findings of fallopian tube cancer lesions synchronized with endometrial cancer. The key differential diagnosis of primary endometriosis-associated endometrioid adenocarcinoma of the fallopian tube from endometrial adenocarcinoma involvement relies on the pathological identification of malignant transformation in fallopian tube endometriosis disease.
子宫内膜异位症是一种影响育龄女性的常见妇科疾病。其特征为子宫外子宫内膜的癌样侵袭，且与卵巢透明细胞癌和子宫内膜样癌密切相关。与子宫内膜样腺癌同步发生的子宫内膜异位症相关输卵管子宫内膜样腺癌鲜有报道。
一名49岁女性因药物治疗效果不佳，出现三年异常阴道出血症状后转诊至我院。术中冰冻切片意外发现左侧输卵管子宫内膜样癌伴浅表浸润，周围为弥漫性子宫内膜异位症，与子宫内膜样子宫内膜癌同步发生。
当遇到与子宫内膜癌同步发生的输卵管癌病变的偶然发现时，很难进行鉴别诊断。原发性子宫内膜异位症相关输卵管子宫内膜样腺癌与子宫内膜腺癌累及的关键鉴别诊断依赖于输卵管子宫内膜异位症疾病中恶性转化的病理鉴定。
