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皮下注射曲前列尼尔治疗小儿肺动脉高压三例报告

Subcutaneous use of treprostinil in pediatric pulmonary hypertension patients: A report of three cases.

作者信息

Kavgacı Akif, Kula Serdar, İncedere Fatma, Terlemez Semiha, Tunaoğlu Fatma Sedef

机构信息

Department of Pediatrics, Division of Pediatric Cardiology, Gazi University Faculty of Medicine, Ankara, Türkiye.

出版信息

Turk Gogus Kalp Damar Cerrahisi Derg. 2023 Jan 30;31(1):145-148. doi: 10.5606/tgkdc.dergisi.2023.23748. eCollection 2023 Jan.

DOI:10.5606/tgkdc.dergisi.2023.23748
PMID:36926146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10012979/
Abstract

Treprostinil was approved by the United States Food and Drug Administration for use in the treatment of pulmonary arterial hypertension in 2002. Intravenous or subcutaneous treprostinil is used in pulmonary arterial hypertension patients in the functional classes of II-IV to alleviate exercise-related symptoms, or in cases where epoprostenol treatment should be reduced due to side effects. In this article, we describe three pediatric cases of pulmonary arterial hypertension in whom subcutaneous treprostinil was used.

摘要

曲前列尼尔于2002年获得美国食品药品监督管理局批准，用于治疗肺动脉高压。静脉注射或皮下注射曲前列尼尔用于治疗功能分级为II-IV级的肺动脉高压患者，以缓解与运动相关的症状，或用于因副作用而应减少依前列醇治疗的情况。在本文中，我们描述了三例使用皮下注射曲前列尼尔治疗的儿童肺动脉高压病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5a/10012979/4b32b36768ca/TJTCS-2023-31-1-145-148-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5a/10012979/17214aaa96f7/TJTCS-2023-31-1-145-148-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5a/10012979/4b32b36768ca/TJTCS-2023-31-1-145-148-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5a/10012979/17214aaa96f7/TJTCS-2023-31-1-145-148-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5a/10012979/4b32b36768ca/TJTCS-2023-31-1-145-148-F2.jpg

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本文引用的文献

1
Use of Treprostinil in Pediatric Pulmonary Hypertension: Case Reports and Review of the Literature.特罗培南在小儿肺动脉高压中的应用：病例报告及文献复习。
J Cardiovasc Pharmacol. 2020 Jul;76(1):23-31. doi: 10.1097/FJC.0000000000000820.
2
2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT.2019 年更新的儿童肺动脉高压诊断和治疗共识声明：欧洲儿科肺血管疾病网络（EPPVDN），得到 AEPC、ESPR 和 ISHLT 的认可。
J Heart Lung Transplant. 2019 Sep;38(9):879-901. doi: 10.1016/j.healun.2019.06.022. Epub 2019 Jun 21.
3
Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension.
口服曲前列尼尔用于小儿肺动脉高压的过渡治疗或附加治疗。
Pulm Circ. 2019 Jul-Sep;9(3):2045894019856471. doi: 10.1177/2045894019856471.
4
Safety, efficacy and Management of subcutaneous treprostinil infusions in the treatment of severe pediatric pulmonary hypertension.在治疗严重小儿肺动脉高压中皮下注射曲前列尼尔的安全性、疗效和管理。
Int J Cardiol. 2018 Aug 1;264:153-157. doi: 10.1016/j.ijcard.2018.03.067. Epub 2018 Mar 15.
5
Use of subcutaneous treprostinil in pediatric pulmonary arterial hypertension-Bridge-to-transplant or long-term treatment?皮下注射曲前列尼尔在儿童肺动脉高压中的应用——过渡到移植还是长期治疗？
Pediatr Transplant. 2018 Mar;22(2). doi: 10.1111/petr.13106. Epub 2017 Dec 19.