Santhanam U, Lalitha V S, Bhide S V
Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Bombay, India.
Int J Cancer. 1987 Dec 15;40(6):784-7. doi: 10.1002/ijc.2910400613.
The effect of suboptimal levels of dietary vitamin A on diethylnitrosamine (DEN) carcinogenesis was studied in BALB/c and Swiss mice. Two different dietary regimens were employed to induce vitamin A deficiency and DEN was administered by gavage at 2 dose levels: 0.6 mg/kg as a single dose and 200 mg/kg in 4 divided doses. Shark liver oil (SLO) which was the main source of vitamin A in the standard diet, was deleted in one regimen and reduced to 25% in the other. The mice maintained on the former diet were given a high dose of DEN and those on the latter diet received a low dose. In both strains the deficient mice had a greater tumour incidence than those on standard diet with a marginal reduction in the latent period. At the low level of DEN there was shift in organotrophy, i.e. from liver in controls to lung in the vitamin-A-deficient mice of BALB/c strain. With the higher dose, lung adenomas predominated in deficient as well as control groups in both the strains. Forestomach carcinomas appeared in deficient mice and not in the controls.
在BALB/c和瑞士小鼠中研究了膳食维生素A水平欠佳对二乙基亚硝胺（DEN）致癌作用的影响。采用两种不同的饮食方案诱导维生素A缺乏，通过灌胃以两种剂量水平给予DEN：单剂量0.6 mg/kg和分4次给予200 mg/kg。标准饮食中维生素A的主要来源鲨鱼肝油（SLO），在一种方案中被去除，在另一种方案中减少到25%。采用前一种饮食的小鼠给予高剂量DEN，采用后一种饮食的小鼠给予低剂量DEN。在两个品系中，缺乏维生素A的小鼠比标准饮食的小鼠肿瘤发生率更高，潜伏期略有缩短。在低剂量DEN时，器官嗜性发生了改变，即从对照组的肝脏转移到BALB/c品系维生素A缺乏小鼠的肺。高剂量时，两个品系的缺乏组和对照组中肺腺瘤均占主导。前胃癌出现在缺乏维生素A的小鼠中，而对照组未出现。
