Khanduja K L, Koul I B, Gandhi R K, Sehgal S, Sharma R R
Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Cancer Lett. 1992 Feb 14;62(1):57-62. doi: 10.1016/0304-3835(92)90198-5.
The present investigation shows the effect of combined dietary deprivation of fat and vitamin A on N-nitrosodiethylamine (NDEA) induced lung carcinogenesis in male Swiss NMRI mice. Lung tumors were induced by three intragastric administrations of NDEA (80, 80, 40, mg/kg body wt.) in normal saline with a gap of 4 weeks between each administration. The tumor incidence and tumor burden in control animals were found to be 39.1 and 3.9%, respectively. Fat deficiency decreased the tumor incidence to 30.4% and tumor burden to 3.7%. On the other hand, vitamin A deficiency increased them to 95.6 and 6.8%, respectively. Fat deprivation in the diet of animals fed with vitamin A deficient diet decreased the tumor burden and tumor incidence to 59.0 and 4.0%, respectively which were still more than in the control animals. This study suggests a protective role for low intake of fat in vitamin A deficiency.
本研究显示了脂肪和维生素A联合膳食缺乏对N-亚硝基二乙胺（NDEA）诱导的雄性瑞士NMRI小鼠肺癌发生的影响。通过在生理盐水中三次灌胃给予NDEA（80、80、40mg/kg体重）诱导肺肿瘤，每次给药间隔4周。发现对照动物的肿瘤发生率和肿瘤负荷分别为39.1%和3.9%。脂肪缺乏使肿瘤发生率降至30.4%，肿瘤负荷降至3.7%。另一方面，维生素A缺乏分别将它们提高到95.6%和6.8%。在喂食维生素A缺乏饮食的动物饮食中剥夺脂肪，可将肿瘤负荷和肿瘤发生率分别降至59.0%和4.0%，但仍高于对照动物。这项研究表明在维生素A缺乏时低脂肪摄入具有保护作用。
