硝苯地平诱导的迟发型超敏反应皮肤试验中的低反应性。
Nifedipine-induced hyporeactivity in delayed hypersensitivity skin tests.
作者信息
Derenne F, Vanhaeverbeek M, Brohée D
机构信息
Department of Internal Medicine, C.H.U. André Vésale, Université Libre de Bruxelles, Montigny-le-Tilleul, Belgium.
出版信息
Int J Immunopharmacol. 1987;9(6):741-4. doi: 10.1016/0192-0561(87)90046-4.
Four patients and three healthy volunteers were submitted to delayed hypersensitivity skin tests to candidin, tuberculin, streptokinase/streptodornase (SK/SD) and mumps antigen before and after a 1 week treatment with nifedipine 10 mg q. 8h. A decrease in the scores of induration and erythema was observed, especially in response to SK/SD antigen challenge. We conclude that nifedipine may induce an anergy status in delayed hypersensitivity skin tests.
4名患者和3名健康志愿者在接受硝苯地平10毫克，每8小时一次，为期1周的治疗前后，均接受了针对念珠菌素、结核菌素、链激酶/链道酶（SK/SD）和腮腺炎抗原的迟发型超敏皮肤试验。观察到硬结和红斑评分下降，尤其是对SK/SD抗原激发的反应。我们得出结论，硝苯地平可能在迟发型超敏皮肤试验中诱导无反应状态。
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