Gondos B
Department of Pathology, University of Connecticut Health Center, Farmington.
Int J Gynecol Pathol. 1987;6(2):114-23. doi: 10.1097/00004347-198706000-00003.
Electron microscopic studies were performed on human fetal ovaries to gain insight into the process of mitotic proliferation in developing germ cells. Three stages of germ cell differentiation are present during the early gestational period: primitive germ cells, oogonia, and oocytes. Oogonia, representing the mitotic stage of differentiation, are the predominant cell type present between 9 and 12 weeks' gestation and then progressively decrease in number as a result of transformation into oocytes in meiosis and degeneration. Mitotic division of oogonia, which is extensive during the late first and early second trimesters, is characterized by incomplete separation and persistence of intercellular bridges between germ cells. Intercellular bridges were found in large numbers from 10 weeks until the time of follicle formation at midgestation. The bridges contained microtubule arrays consistent with remnants of the spindle apparatus. The findings support the role of germ cell bridges in maintaining coordination of proliferative activity during the early developmental period.
对人类胎儿卵巢进行了电子显微镜研究，以深入了解发育中的生殖细胞有丝分裂增殖过程。在妊娠早期存在三个生殖细胞分化阶段：原始生殖细胞、卵原细胞和卵母细胞。卵原细胞代表分化的有丝分裂阶段，是妊娠9至12周期间存在的主要细胞类型，然后由于减数分裂转化为卵母细胞和退化，其数量逐渐减少。卵原细胞的有丝分裂在妊娠晚期的头三个月和早期的第二个三个月期间广泛存在，其特征是生殖细胞之间的细胞间桥不完全分离并持续存在。从10周直到妊娠中期卵泡形成时，大量发现细胞间桥。这些桥包含与纺锤体残余物一致的微管阵列。这些发现支持了生殖细胞桥在早期发育阶段维持增殖活动协调中的作用。
