Gondos B, Westergaard L, Byskov A G
Am J Obstet Gynecol. 1986 Jul;155(1):189-95. doi: 10.1016/0002-9378(86)90109-2.
Ovaries from 27 human fetuses at less than or equal to 12 weeks' gestational age were examined with electron microscopy and squash preparation studies. The findings demonstrated that meiosis begins in the fetal ovary between 11 and 12 weeks of age. This is several weeks after gonadal sex differentiation, which can be recognized in the testis at 6 weeks. Ovaries at earlier ages included primitive germ cells and oogonia. With advancing fetal age, mitotic activity and germ cell degeneration became increasingly evident. Preleptotene cells were found as early as 9 to 10 weeks, suggesting that meiotic capacity is present soon after gonadal sex differentiation but further progression into meiosis is delayed until some specific inductive influence is exerted.
对27例孕龄小于或等于12周的人类胎儿卵巢进行了电子显微镜检查和压片制备研究。研究结果表明，减数分裂在胎儿卵巢中于11至12周龄时开始。这比性腺性别分化晚几周，性腺性别分化在6周时可在睾丸中识别。早期的卵巢包括原始生殖细胞和卵原细胞。随着胎儿年龄的增长，有丝分裂活性和生殖细胞退化变得越来越明显。早在9至10周就发现了前细线期细胞，这表明减数分裂能力在性腺性别分化后不久就存在，但减数分裂的进一步进展会延迟，直到受到某些特定的诱导影响。
