Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Department of Preventive Dental Sciences, College of Dentistry, Majmaah University, Al-Majmaah, Saudi Arabia.
Photobiomodul Photomed Laser Surg. 2023 Mar;41(3):133-139. doi: 10.1089/photob.2022.0155.
To assess the efficiency of photodynamic therapy (PDT) adjunct to full mouth scaling (FMS) in improving periodontal, microbiological, and proinflammatory cytokines levels in patients undergoing fixed orthodontics treatment (FOT). The study recruited 60 teenage patients who were undergoing FOT. All the patients were arbitrarily divided into two groups: Group 1, FMS +PDT and Group 2, FMS alone. Plaque scores (PS), bleeding on probing (BOP), and probing depth (PD) were assessed. Levels of biomarkers interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-α) using enzyme-linked immunosorbent assay were evaluated. Samples were collected from gingival plaque for estimation of and load. All measurements were completed at three intervals baseline, 4th week, and 8th week. Post Hoc corrections and intergroup comparisons were examined using Student's -test and Bonferroni correction. To find differences between repeated follow-ups, analysis of variance (ANOVA) multiple rank tests were used. At baseline, all the gingival parameters displayed comparable outcomes between patients of Group 1 and Group 2 ( > 0.05). However, at 4 and 8 weeks of follow-up, PS and BOP among tested groups exhibited significantly lower values than baseline ( < 0.001). At 8 weeks, there was a significant difference in PS between the two groups tested. Moreover, at 4 and 8 weeks, BOP revealed a significant difference between the groups. PD remains comparable with baseline at follow-up visits ( > 0.05). A significant decrease in IL-6 and TNF-α levels was observed in both investigated groups at 4 and 8 weeks of baseline. Moreover, it was identified that and were reduced significantly at 4 weeks. Moreover, a significant difference existed between both Group 1 and Group 2 at 4 and 8 weeks of recall visit ( < 0.05). The use of photodynamic treatment adjuvant to FMS aids in improving periodontal parameters and cytokines levels.
评估光动力疗法（PDT）辅助全口洁治（FMS）在改善接受固定正畸治疗（FOT）的患者牙周、微生物和促炎细胞因子水平方面的效率。该研究招募了 60 名正在接受 FOT 的青少年患者。所有患者均被随机分为两组：组 1，FMS+PDT；组 2，单独 FMS。评估菌斑指数（PS）、探诊出血（BOP）和探诊深度（PD）。采用酶联免疫吸附试验评估生物标志物白细胞介素（IL）-6 和肿瘤坏死因子-α（TNF-α）的水平。从牙龈菌斑中取样，估计 和 负荷。所有测量均在基线、第 4 周和第 8 周三个时间点完成。使用 Student's -test 和 Bonferroni 校正检查后验校正和组间比较。为了发现重复随访之间的差异，使用方差分析（ANOVA）多重等级检验进行分析。在基线时，组 1 和组 2 的所有牙龈参数显示出可比的结果（>0.05）。然而，在 4 和 8 周的随访中，测试组的 PS 和 BOP 值明显低于基线（<0.001）。在第 8 周，两组之间的 PS 存在显著差异。此外，在 4 和 8 周时，两组之间的 BOP 存在显著差异。在随访时，PD 与基线相比保持可比（>0.05）。在基线的 4 和 8 周时，两组均观察到 IL-6 和 TNF-α水平显著下降。此外，在 4 周时发现 和 显著减少。此外，在第 4 和 8 周的随访时，两组之间存在显著差异（<0.05）。FMS 辅助 PDT 的使用有助于改善牙周参数和细胞因子水平。
