Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.
Department of General Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Photodiagnosis Photodyn Ther. 2023 Jun;42:103494. doi: 10.1016/j.pdpdt.2023.103494. Epub 2023 Mar 5.
To compare the efficacy of surgical periodontal treatment (SPT) alone and PDT-assisted surgery in participants with severe periodontitis.
The present clinical trial was completed by 64 participants (n = 32 each). The selection was made according to predefined inclusion and exclusion criteria. Patients in group A were treated with SPT only and participants in group B were treated with SPT adjunct to PDT. Microbiological assessment of P.Gingivalis; T. Forsythia and T.Denticola were evaluated using cultural analysis and periodontal parameters plaque score (PSc), bleeding on probing (BoP) periodontal depth (PD), and clinical attachment loss (CAL) at baseline and post-treatment at 6 months and 12 months were performed. The gingival crevicular fluid (GCF) was collected for the estimation of IL-1β and tumor necrosis factor-alpha (TNF-α) using an enzyme-linked immunosorbent assay (ELISA). For intra-group comparison and post hoc correction, Student's t-test along with Bonferroni was used. For the difference between follow-ups, an analysis of variance (ANOVA) multiple rank tests were incorporated.
The mean age of participants in the SPT group was 55.25±4.6yrs. Whereas, participants treated with PDT adjunct to SPT were 54.88±3.6yrs. Periodontal parameters (BoP, PD, PSc, CAL) showed no significant difference at baseline. At 6 months and 12 months follow-up, a significant difference in all parameters (BoP, PD, PSc, and CAL) was found in participants treated with SPT alone and PDT adjunct to SPT (p<0.05). Inflammatory biomarkers at 6-month and 12-month follow-ups, a statistically significant difference in the level of biomarkers (IL-1β and TNF-α) were observed in both groups from baseline (p<0.05). However, at baseline, no significant difference was noted in both groups (p> 0.05). The microbiological assessment showed a significant drop in the bacterial count in participants treated with both regimes i.e., SPT alone and PDT adjunct to SPT.
Photodynamic therapy (PDT) adjunct to surgical periodontal treatment (SPT) in severe periodontitis improves microbiological and periodontal parameters and lowers the level of proinflammatory cytokines.
比较单独牙周手术治疗（SPT）和 PDT 辅助手术治疗在重度牙周炎患者中的疗效。
本临床试验由 64 名参与者（n=32 名）完成。根据预设的纳入和排除标准进行选择。A 组患者仅接受 SPT 治疗，B 组患者接受 SPT 联合 PDT 治疗。采用培养分析评估 P.Gingivalis；T. Forsythia 和 T.Denticola；在基线和治疗后 6 个月和 12 个月时，评估牙周参数菌斑指数（PSc）、探诊出血（BoP）、牙周袋深度（PD）和临床附着丧失（CAL）。采用酶联免疫吸附试验（ELISA）法检测龈沟液（GCF）中白细胞介素-1β（IL-1β）和肿瘤坏死因子-α（TNF-α）的含量。采用学生 t 检验和 Bonferroni 进行组内比较和事后校正。采用方差分析（ANOVA）多等级检验比较随访间差异。
SPT 组患者的平均年龄为 55.25±4.6 岁，而接受 PDT 辅助 SPT 治疗的患者的平均年龄为 54.88±3.6 岁。基线时，牙周参数（BoP、PD、PSc、CAL）无显著性差异。在 6 个月和 12 个月的随访中，单独接受 SPT 治疗和 PDT 辅助 SPT 治疗的患者的所有参数（BoP、PD、PSc 和 CAL）均有显著差异（p<0.05）。在 6 个月和 12 个月的随访中，两组患者的炎症生物标志物（IL-1β 和 TNF-α）水平均有统计学差异（p<0.05）。然而，两组患者在基线时均无显著差异（p>0.05）。微生物评估显示，单独接受 SPT 治疗和 PDT 辅助 SPT 治疗的患者的细菌计数均显著下降。
PDT 辅助 SPT 治疗重度牙周炎可改善微生物和牙周参数，并降低促炎细胞因子水平。
