Passing the βAR: PI3Kγ Is the Judge of β Adrenergic Receptor Resensitization.
作者信息
Quiles Justin M, Gustafsson Åsa B
机构信息
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla.
出版信息
Circ Res. 2023 Mar 17;132(6):704-706. doi: 10.1161/CIRCRESAHA.123.322554. Epub 2023 Mar 16.
Abstract
摘要
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本文引用的文献
1
Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ.β-肾上腺素受体的缺氧感应受内体 PI3Kγ 调节。
Circ Res. 2023 Mar 17;132(6):690-703. doi: 10.1161/CIRCRESAHA.122.321735. Epub 2023 Feb 13.
2
G protein-coupled receptor kinases as therapeutic targets in the heart.G 蛋白偶联受体激酶作为心脏治疗靶点。
Nat Rev Cardiol. 2019 Oct;16(10):612-622. doi: 10.1038/s41569-019-0220-3. Epub 2019 Jun 11.
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Hypoxia sensing through -adrenergic receptors.通过β-肾上腺素能受体进行缺氧感知。
JCI Insight. 2016 Dec 22;1(21):e90240. doi: 10.1172/jci.insight.90240.
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Cardiac β2-Adrenergic Receptor Phosphorylation at Ser355/356 Regulates Receptor Internalization and Functional Resensitization.心脏β2-肾上腺素能受体Ser355/356位点的磷酸化调控受体的内化及功能再敏化。
PLoS One. 2016 Aug 19;11(8):e0161373. doi: 10.1371/journal.pone.0161373. eCollection 2016.
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The evolving impact of g protein-coupled receptor kinases in cardiac health and disease.G蛋白偶联受体激酶在心脏健康与疾病中的演变影响。
Physiol Rev. 2015 Apr;95(2):377-404. doi: 10.1152/physrev.00015.2014.
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Inhibition of protein phosphatase 2A activity by PI3Kγ regulates β-adrenergic receptor function.PI3Kγ 通过抑制蛋白磷酸酶 2A 的活性来调节β-肾上腺素能受体功能。
Mol Cell. 2011 Mar 18;41(6):636-48. doi: 10.1016/j.molcel.2011.02.025.
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Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation.心力衰竭中心β2-肾上腺素能受体再分布改变了 cAMP 的区室化。
Science. 2010 Mar 26;327(5973):1653-7. doi: 10.1126/science.1185988. Epub 2010 Feb 25.
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The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification.隔离在G蛋白偶联受体再敏化中的作用。囊泡酸化对β2 -肾上腺素能受体去磷酸化的调节。
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